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In enzymology, a hydroxylamine reductase (NADH) (EC 1.7.1.10) is an enzyme that catalyzes the chemical reaction.

NH₃ + NAD + H₂O ${\displaystyle \rightleftharpoons }$ hydroxylamine + NADH + H

The 3 substrates of this enzyme are NH₃, NAD, and H₂O, whereas its 3 products are hydroxylamine, NADH, and H.

This enzyme belongs to the family of oxidoreductases, specifically those acting on other nitrogenous compounds as donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is ammonium:NAD+ oxidoreductase. Other names in common use include hydroxylamine reductase, ammonium dehydrogenase, NADH-hydroxylamine reductase, N-hydroxy amine reductase, hydroxylamine reductase (NADH2), and NADH2:hydroxylamine oxidoreductase. This enzyme participates in nitrogen metabolism.

References

• Bernheim ML (1969). "The hydroxylamine reductase of mitochondria". Arch. Biochem. Biophys. 134 (2): 408–13. doi:10.1016/0003-9861(69)90300-2. PMID 4311180.
• Bernheim ML, Hochstein P (1968). "Reduction of hydroxylamine by rat liver mitochondria". Arch. Biochem. Biophys. 124 (1): 436–42. doi:10.1016/0003-9861(68)90349-4. PMID 4298499.
• Wang R, Nicholas DJ (1986). "Some properties of nitrite and hydroxylamine reductases from Derxia gummosa". Phytochemistry. 25 (11): 2463–2469. doi:10.1016/S0031-9422(00)84489-1.

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