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ITIH4
Identifiers
Aliases	ITIH4, GP120, H4P, IHRP, ITI-HC4, ITIHL1, PK-120, PK120, inter-alpha-trypsin inhibitor heavy chain family member 4, inter-alpha-trypsin inhibitor heavy chain 4
External IDs	OMIM: 600564; MGI: 109536; HomoloGene: 1670; GeneCards: ITIH4; OMA:ITIH4 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3p21.1 Start 52,812,962 bp End 52,830,688 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14 B|14 19.09 cM Start 30,608,433 bp End 30,624,310 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver right coronary artery popliteal artery tibial arteries left coronary artery body of pancreas muscle of thigh sperm right adrenal cortex gastrocnemius muscle Top expressed in left lobe of liver ascending aorta aortic valve gallbladder tunica media of zone of aorta right lung lobe carotid body sexually immature organism fetal liver hematopoietic progenitor cell embryo More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase inhibitor activity endopeptidase inhibitor activity protein binding serine-type endopeptidase inhibitor activity Cellular component cytoplasm plasma membrane blood microparticle extracellular exosome platelet dense granule lumen extracellular region collagen-containing extracellular matrix Biological process response to cytokine negative regulation of peptidase activity acute-phase response hyaluronan metabolic process platelet degranulation negative regulation of endopeptidase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3700 16427 Ensembl ENSG00000055955 ENSMUSG00000021922 UniProt Q14624 A6X935 RefSeq (mRNA) NM_002218 NM_001166449 NM_001159299 NM_001289632 NM_001289633 NM_018746 RefSeq (protein) NP_001159921 NP_002209 NP_001152771 NP_001276561 NP_001276562 NP_061216 Location (UCSC) Chr 3: 52.81 – 52.83 Mb Chr 14: 30.61 – 30.62 Mb PubMed search
Wikidata
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Inter-alpha-trypsin inhibitor heavy chain H4 is a protein that in humans is encoded by the ITIH4 gene.

See also

• Inter-alpha-trypsin inhibitor
• ITIH1
• ITIH2
• ITIH3

References

1. ^ GRCh38: Ensembl release 89: ENSG00000055955 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000021922 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Soury E, Olivier E, Daveau M, Hiron M, Claeyssens S, Risler JL, Salier JP (Mar 1998). "The H4P heavy chain of inter-alpha-inhibitor family largely differs in the structure and synthesis of its prolin-rich region from rat to human". Biochem Biophys Res Commun. 243 (2): 522–30. doi:10.1006/bbrc.1998.8128. PMID 9480842.
6. Nishimura H, Kakizaki I, Muta T, Sasaki N, Pu PX, Yamashita T, Nagasawa S (Feb 1995). "cDNA and deduced amino acid sequence of human PK-120, a plasma kallikrein-sensitive glycoprotein". FEBS Lett. 357 (2): 207–11. Bibcode:1995FEBSL.357..207H. doi:10.1016/0014-5793(94)01364-7. PMID 7805892.
7. "Entrez Gene: ITIH4 inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)".

Further reading

• Choi-Miura NH, Sano Y, Oda E, et al. (1995). "Purification and characterization of a novel glycoprotein which has significant homology to heavy chains of inter-alpha-trypsin inhibitor family from human plasma". J. Biochem. 117 (2): 400–7. doi:10.1093/jb/117.2.400. PMID 7541790.
• Tobe T, Saguchi K, Hashimoto K, et al. (1995). "Mapping of human inter-alpha-trypsin inhibitor family heavy chain-related protein gene (ITIHL1) to human chromosome 3p21→p14". Cytogenet. Cell Genet. 71 (3): 296–8. doi:10.1159/000134130. PMID 7587397.
• Saguchi K, Tobe T, Hashimoto K, et al. (1995). "Cloning and characterization of cDNA for inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP), a novel human plasma glycoprotein". J. Biochem. 117 (1): 14–8. doi:10.1093/oxfordjournals.jbchem.a124701. PMID 7775381.
• Saguchi K, Tobe T, Hashimoto K, et al. (1997). "Isolation and characterization of the human inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP) gene (ITIHL1)". J. Biochem. 119 (5): 898–905. doi:10.1093/oxfordjournals.jbchem.a021327. PMID 8797089.
• Jean L, Smih F, Olivier E, et al. (1997). "Comparative assignments of the genes of the inter-alpha-inhibitor family in human and mouse: ITIH4 is close to ITIH1 and ITIH3, on HSA 3 and MMU 14". Genomics. 41 (1): 139–40. doi:10.1006/geno.1997.4612. PMID 9126497.
• Diarra-Mehrpour M, Sarafan N, Bourguignon J, et al. (1998). "Human inter-alpha-trypsin inhibitor heavy chain H3 gene. Genomic organization, promoter analysis, and gene linkage". J. Biol. Chem. 273 (41): 26809–19. doi:10.1074/jbc.273.41.26809. PMID 9756925.
• Tozaki T, Choi-Miura NH, Taniyama M, et al. (2003). "SNP analysis of the inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP) gene by a fluorescence-adapted SSCP method". BMC Med. Genet. 3: 6. doi:10.1186/1471-2350-3-6. PMC 117798. PMID 12147176.
• Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry". Nat. Biotechnol. 21 (6): 660–6. doi:10.1038/nbt827. PMID 12754519. S2CID 581283.
• Fujita Y, Ezura Y, Emi M, et al. (2004). "Hypercholesterolemia associated with splice-junction variation of inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) gene". J. Hum. Genet. 49 (1): 24–8. doi:10.1007/s10038-003-0101-8. PMID 14661079.
• Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Mol. Cell. Proteomics. 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
• Bunkenborg J, Pilch BJ, Podtelejnikov AV, Wiśniewski JR (2004). "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry". Proteomics. 4 (2): 454–65. doi:10.1002/pmic.200300556. PMID 14760718. S2CID 29261009.
• Kroczynska B, King-Simmons L, Alloza L, et al. (2006). "BIP co-chaperone MTJ1/ERDJ1 interacts with inter-alpha-trypsin inhibitor heavy chain 4". Biochem. Biophys. Res. Commun. 338 (3): 1467–77. doi:10.1016/j.bbrc.2005.10.101. PMID 16271702.
• Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.

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