Impellizzeri is an Italian surname. Notable people with the surname include:
- Brian Lionel Impellizzeri (born 1998) Argentine Paralympic athlete
- Charles Impellizzeri (died 1656), Italian Roman Catholic bishop
- Nunzio Impellizzeri (born 1980), Italian choreographer
- Shirley Impellizzeri, American clinical psychologist
- Simone Impellizzeri (died 1701), Italian Roman Catholic bishop
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