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Jumping translocation breakpoint

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(Redirected from JTB (gene)) Protein-coding gene in the species Homo sapiens
JTB
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2KJX

Identifiers
AliasesJTB, HHSPC222, PAR, hJT, jumping translocation breakpoint
External IDsOMIM: 604671; MGI: 1346082; HomoloGene: 4870; GeneCards: JTB; OMA:JTB - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)
Chromosome 1 (human)Genomic location for JTBGenomic location for JTB
Band1q21.3Start153,974,269 bp
End153,977,674 bp
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)
Chromosome 3 (mouse)Genomic location for JTBGenomic location for JTB
Band3|3 F1Start90,138,904 bp
End90,143,145 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • parotid gland

  • mucosa of ileum

  • mucosa of sigmoid colon

  • tibia

  • pancreatic ductal cell

  • body of pancreas

  • skin of thigh

  • Pituitary Gland

  • anterior pituitary

  • Epithelium of choroid plexus
Top expressed in
  • parotid gland

  • Ileal epithelium

  • saccule

  • seminal vesicula

  • Paneth cell

  • lacrimal gland

  • epithelium of lens

  • triceps brachii muscle

  • sternocleidomastoid muscle

  • vastus lateralis muscle
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10899

23922

Ensembl

ENSG00000143543

ENSMUSG00000027937

UniProt

O76095

O88824

RefSeq (mRNA)

NM_006694

NM_206924

RefSeq (protein)

NP_006685

NP_996807

Location (UCSC)Chr 1: 153.97 – 153.98 MbChr 3: 90.14 – 90.14 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse
Protein family
Jumping translocation breakpoint protein (JTB)
Identifiers
SymbolJTB
PfamPF05439
InterProIPR008657
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

The jumping translocation breakpoint protein (JTB), also known as prostate androgen-regulated protein (PAR), is a protein that in humans is encoded by the JTB gene. It is an orphan receptor with unknown function.

The JTB family of proteins contains several jumping translocation breakpoint proteins or JTBs. Jumping translocation (JT) is an unbalanced translocation that comprises amplified chromosomal segments jumping to various telomeres. JTB has been found to fuse with the telomeric repeats of acceptor telomeres in a case of JT. Homo sapiens JTB (hJTB) encodes a transmembrane protein that is highly conserved among divergent eukaryotic species. JT results in a hJTB truncation, which potentially produces an hJTB product devoid of the transmembrane domain. hJTB is located in a gene-rich region at 1q21, called epidermal differentiation complex (EDC). JTB has also been implicated in prostatic carcinomas.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000143543Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000027937Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hatakeyama S, Osawa M, Omine M, Ishikawa F (Jun 1999). "JTB: a novel membrane protein gene at 1q21 rearranged in a jumping translocation". Oncogene. 18 (12): 2085–90. doi:10.1038/sj.onc.1202510. PMID 10321732.
  6. "Entrez Gene: JTB jumping translocation breakpoint".
  7. Rousseau, Francois; Pan, Borlan; Fairbrother, Wayne J.; Bazan, J. Fernando; Lingel, Andreas (January 2012). "The Structure of the Extracellular Domain of the Jumping Translocation Breakpoint Protein Reveals a Variation of the Midkine Fold". Journal of Molecular Biology. 415 (1): 22–28. doi:10.1016/j.jmb.2011.10.048. PMID 22079049.
  8. Platica O, Chen S, Ivan E, Lopingco MC, Holland JF, Platica M (May 2000). "PAR, a novel androgen regulated gene, ubiquitously expressed in normal and malignant cells". Int. J. Oncol. 16 (5): 1055–61. doi:10.3892/ijo.16.5.1055. PMID 10762645.

Further reading

External links

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Protein JTB


This article incorporates text from the public domain Pfam and InterPro: IPR008657 Categories:
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