| Names | |
|---|---|
| IUPAC name N-(2-Phenylacetyl)-L-tyrosyl-D-arginyl-L-α-aspartyl-L-alanyl-L-isoleucyl-4-chloro-L-phenylalanyl-L-threonyl-L-asparaginyl-N6-(aminoiminomethyl)-L-lysyl-O-methyl-L-tyrosyl-L-arginyl-L-lysyl-L-valyl-L-leucyl-(2S)-2-aminobutanoyl-L-glutaminyl-L-leucyl-L-seryl-L-alanyl-L-arginyl-L-lysyl-L-leucyl-L-leucyl-L-glutaminyl-L-α-aspartyl-L-isoleucyl-L-norleucyl-D-arginyl-N6-(aminoiminomethyl)-L-lysinamide | |
| Other names Phenylacetyl-(D-Arg·,p-chloro-Phe,Homoarg·,Tyr(Me),Abu,Nle)-Sermorelin | |
| Identifiers | |
| CAS Number | |
| Properties | |
| Chemical formula | C172H284ClN53O41 |
| Molar mass | 3785.94 g·mol |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references | |
JV-1-36 is a GHRH antagonist that has been shown to inhibit endometriotic cell proliferation and survival, suggesting that GHRH antagonist may represent promising tools for treatment of endometriosis.
References
- Annunziata M, Grande C, Scarlatti F, et al. (June 2009). "The growth hormone-releasing hormone (GHRH) antagonist JV-1-36 inhibits proliferation and survival of human ectopic endometriotic stromal cells (ESCs) and the T HESC cell line". Fertil. Steril. 94 (3): 841–849. doi:10.1016/j.fertnstert.2009.03.093. PMID 19524226.
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