Karakashian or Karakashyan (Armenian: Կարակաշյան) is an Armenian surname that may refer to:
- Narine Karakashian (born 1971), Armenian chess player
- Verkine Karakashian (1856–1933), Ottoman-Armenian actress and soprano
- Yeranuhi Karakashian (1848–1924), Ottoman-Armenian actress
- Nonna Karakashyan (born 1940), Armenian chess player
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