KCND1

(Redirected from Kv4.1) Protein-coding gene in the species Homo sapiens

KCND1

Identifiers

KCND1, KV4.1, potassium voltage-gated channel subfamily D member 1

External IDs

OMIM: 300281; MGI: 96671; HomoloGene: 21035; GeneCards: KCND1; OMA:KCND1 - orthologs

Gene location (Human)

Chr.	X chromosome (human)

Band	Xp11.23	Start	48,961,378 bp
Band	Xp11.23	End	48,971,844 bp

Gene location (Mouse)

Chr.	X chromosome (mouse)

Band	X A1.1\|X 3.53 cM	Start	7,688,528 bp
Band	X A1.1\|X 3.53 cM	End	7,704,519 bp

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

gonad

right hemisphere of cerebellum

left uterine tube

stromal cell of endometrium

Descending thoracic aorta

paraflocculus of cerebellum

ascending aorta

left coronary artery

granulocyte

gallbladder

Top expressed in

lumbar spinal ganglion

facial motor nucleus

granulocyte

gastrula

tail of embryo

anterior horn of spinal cord

genital tubercle

superior frontal gyrus

dentate gyrus of hippocampal formation granule cell

primary visual cortex

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	potassium channel activity metal ion binding voltage-gated ion channel activity ion channel activity A-type (transient outward) potassium channel activity voltage-gated potassium channel activity
Cellular component	integral component of membrane cell projection membrane voltage-gated potassium channel complex plasma membrane soma dendrite cellular component
Biological process	regulation of ion transmembrane transport ion transport potassium ion transport transmembrane transport potassium ion transmembrane transport protein homooligomerization cardiac conduction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3750


16506

Ensembl


ENSG00000102057


ENSMUSG00000009731

UniProt


Q9NSA2


Q03719

RefSeq (mRNA)


NM_004979


NM_008423

RefSeq (protein)


NP_004970


NP_032449

Location (UCSC)

Chr X: 48.96 – 48.97 Mb

PubMed search

Potassium voltage-gated channel, Shal-related subfamily, member 1 (KCND1), also known as K_v4.1, is a human gene.

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This gene is expressed at moderate levels in all tissues analyzed, with lower levels in skeletal muscle.

References

^ GRCh38: Ensembl release 89: ENSG00000102057 – Ensembl, May 2017
^ GRCm38: Ensembl release 89: ENSMUSG00000009731 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: KCND1 potassium voltage-gated channel, Shal-related subfamily, member 1".

Gutman GA, Chandy KG, Grissmer S, et al. (2006). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol. Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.
Kurschner C, Yuzaki M (1999). "Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein". J. Neurosci. 19 (18): 7770–80. doi:10.1523/JNEUROSCI.19-18-07770.1999. PMC 6782450. PMID 10479680.
Isbrandt D, Leicher T, Waldschütz R, et al. (2000). "Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I(TO) and I(SA)". Genomics. 64 (2): 144–54. doi:10.1006/geno.2000.6117. PMID 10729221.
Nakamura TY, Nandi S, Pountney DJ, et al. (2001). "Different effects of the Ca(2+)-binding protein, KChIP1, on two Kv4 subfamily members, Kv4.1 and Kv4.2". FEBS Lett. 499 (3): 205–9. Bibcode:2001FEBSL.499..205N. doi:10.1016/S0014-5793(01)02560-1. PMID 11423117.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Jerng HH, Qian Y, Pfaffinger PJ (2005). "Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10)". Biophys. J. 87 (4): 2380–96. doi:10.1529/biophysj.104.042358. PMC 1304660. PMID 15454437.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kim SJ, Choi WS, Han JS, et al. (2005). "A novel mechanism for the suppression of a voltage-gated potassium channel by glucose-dependent insulinotropic polypeptide: protein kinase A-dependent endocytosis". J. Biol. Chem. 280 (31): 28692–700. doi:10.1074/jbc.M504913200. PMID 15955806.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Membrane transport protein: ion channels (TC 1A)

Ca: Calcium channel

Ligand-gated

Inositol trisphosphate receptor
- 1
- 2
- 3
Ryanodine receptor
- 1
- 2
- 3

Voltage-gated

L-type/Ca_vα
- 1.1
- 1.2
- 1.3
- 1.4
N-type/Ca_vα2.2
P-type/Ca_vα
- 2.1
Q-type/Ca_vα2.1
R-type/Ca_vα2.3
T-type/Ca_vα
- 3.1
- 3.2
- 3.3

α₂δ-subunits
- 1
- 2
β-subunits
- β1
- β2
- β3
- β4
γ-subunits
- γ1
- γ2
- γ3
- γ4

Cation channels of sperm
- 1
- 2
- 3
- 4
Two-pore channel
- 1
- 2

Na: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H: Proton channel	HVCN1
M: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm: Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin

By gating mechanism

Ion channel class	Ligand-gated Light-gated Voltage-gated Stretch-activated

see also disorders

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References

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