Lézignan may refer to:
In geography:
- Lézignan, Hautes-Pyrénées, a commune in the Hautes-Pyrénées department, France
- Lézignan-Corbières, a commune in the Aude department, France
- Lézignan-la-Cèbe, a commune in the Hérault department, France
In other uses:
- Lézignan Sangliers, a rugby league football club based in Lézignan-Corbières
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