L22 may refer to:
Ships
- HMS L22, a submarine of the Royal Navy
- HMS Aldenham (L22), a destroyer of the Royal Navy
- HMS Folkestone (L22), a sloop of the Royal Navy
- INS Kumbhir (L22), an amphibious warfare vessel of the Indian Navy
- Soviet submarine L-22
- Spanish ship Aragón (L-22)
Other uses
- 60S ribosomal protein L22
- L22 carbine, a British carbine assault rifle
- Mitochondrial ribosomal protein L22
- Yucca Valley Airport, in San Bernardino County, California, United States
- Zeppelin LZ 64, an airship of the Imperial German Navy
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