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LIN7A

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Protein-coding gene in humans
LIN7A
Identifiers
AliasesLIN7A, LIN-7A, LIN7, MALS-1, TIP-33, VELI1, lin-7 homolog A, crumbs cell polarity complex component, MALS1
External IDsOMIM: 603380; MGI: 2135609; HomoloGene: 20976; GeneCards: LIN7A; OMA:LIN7A - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)
Chromosome 12 (human)Genomic location for LIN7AGenomic location for LIN7A
Band12q21.31Start80,792,520 bp
End80,937,934 bp
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)
Chromosome 10 (mouse)Genomic location for LIN7AGenomic location for LIN7A
Band10|10 D1Start107,107,547 bp
End107,257,335 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Brodmann area 23

  • endothelial cell

  • middle temporal gyrus

  • retinal pigment epithelium

  • primary visual cortex

  • trabecular bone

  • blood

  • cerebellar cortex

  • cerebellar hemisphere

  • entorhinal cortex
Top expressed in
  • lobe of cerebellum

  • seminiferous tubule

  • cerebellar vermis

  • lateral septal nucleus

  • lumbar spinal ganglion

  • nucleus accumbens

  • neural layer of retina

  • primary motor cortex

  • inferior colliculi

  • superior cervical ganglion
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8825

108030

Ensembl

ENSG00000111052

ENSMUSG00000019906

UniProt

O14910

Q8JZS0

RefSeq (mRNA)

NM_004664
NM_001324423

NM_001033223
NM_001039354
NM_001284329

RefSeq (protein)

NP_001311352
NP_004655

NP_001028395
NP_001034443
NP_001271258

Location (UCSC)Chr 12: 80.79 – 80.94 MbChr 10: 107.11 – 107.26 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Lin-7 homolog A is a protein that in humans is encoded by the LIN7A gene.

Interactions

LIN7A has been shown to interact with:

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000111052Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000019906Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Jo K, Derin R, Li M, Bredt DS (Jun 1999). "Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex". J Neurosci. 19 (11): 4189–99. doi:10.1523/JNEUROSCI.19-11-04189.1999. PMC 6782594. PMID 10341223.
  6. Bohl J, Brimer N, Lyons C, Vande Pol SB (Mar 2007). "The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions". J Biol Chem. 282 (13): 9392–400. doi:10.1074/jbc.M610002200. PMID 17237226.
  7. "Entrez Gene: LIN7A lin-7 homolog A (C. elegans)".
  8. ^ Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (Apr 2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. 279 (18): 19051–63. doi:10.1074/jbc.M400284200. PMID 14960569.
  9. Borg JP, Straight SW, Kaech SM, de Taddéo-Borg M, Kroon DE, Karnak D, Turner RS, Kim SK, Margolis B (Nov 1998). "Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting". J. Biol. Chem. 273 (48): 31633–6. doi:10.1074/jbc.273.48.31633. PMID 9822620.
  10. Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (May 2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi:10.1074/jbc.M400285200. PMID 15024025.

Further reading

PDB gallery
  • 2dkr: Solution structure of the PDZ domain from human Lin-7 homolog B 2dkr: Solution structure of the PDZ domain from human Lin-7 homolog B


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