Leo O'Brien may refer to:
- Leo O'Brien (actor) (1970–2012), American television and film actor
- Leo O'Brien (cricketer) (1907–1997), Australian cricketer
- Leo F. O'Brien (1924-1968), American politician, member of the Illinois House of Representatives
- Leo P. O'Brien (1893–1968), American politician, member of the Wisconsin State Senate
- Leo W. O'Brien (1900–1982), American politician, Representative from New York
Topics referred to by the same termThis disambiguation page lists articles about people with the same name. If an internal link led you here, you may wish to change the link to point directly to the intended article. Category: