Liese may refer to:
- Thomas Liese (born 1968), former German professional cyclist
- Peter Liese (born 1965), German politician and Member of the European Parliament
- Fred Liese (1885–1967), pinch hitter in Major League Baseball
- Walter Liese (1926–2023), German forestry and wood researcher and wood biologist
- Liese (Glenne), a river of North Rhine-Westphalia, Germany, tributary of the Glenne
- Liese (Nuhne), a river of North Rhine-Westphalia, Germany, tributary of the Nuhne
- a short form of Elizabeth (given name)
- Single from the special edition of Liebe ist für alle da, by Rammstein
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