Laryngo-onycho-cutaneous syndrome

(Redirected from Logic syndrome) Medical condition

Laryngoonychocutaneous syndrome

This condition is inherited in an autosomal recessive manner.
Specialty	Dermatology

Laryngo-onycho-cutaneous syndrome (also known as Shabbir syndrome) is a rare epithelial disorder inherited in an autosomal recessive fashion. It is characterized by abnormalities in the larynx, nails ("onycho-"), and skin ("cutaneous"). The disorder is only found in Punjabi Muslims and only a few cases have been reported.

It was characterized by Pakistani dermatologist Syed Ghulam Shabbir (1923–2002) in 1986.

It may be associated with LAMA3.

References

Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. p. 712. ISBN 978-1-4160-2999-1.
Bardhan, Ajoy; Bruckner-Tuderman, Leena; Chapple, Iain L. C.; Fine, Jo-David; Harper, Natasha; Has, Cristina; Magin, Thomas M.; Marinkovich, M. Peter; Marshall, John F.; McGrath, John A.; Mellerio, Jemima E. (2020-09-24). "Epidermolysis bullosa". Nature Reviews Disease Primers. 6 (1): 78. doi:10.1038/s41572-020-0210-0. ISSN 2056-676X. PMID 32973163. S2CID 221861310.
"Laryngo-onycho-cutaneous syndrome: MedlinePlus Genetics". medlineplus.gov. Retrieved 2020-11-01.
McLean, W. H. I. (2003-07-15). "An unusual N-terminal deletion of the laminin 3a isoform leads to the chronic granulation tissue disorder laryngo-onycho-cutaneous syndrome". Human Molecular Genetics. 12 (18): 2395–2409. doi:10.1093/hmg/ddg234. ISSN 1460-2083. PMID 12915477.
Journal of Pakistan Association of Dermatologists 2010; 20: 125-127.
Shabbir, G., Hassan, M., Kazmi, A. Laryngo-onycho-cutaneous syndrome: a study of 22 cases. Biomedica 2: 15-25, 1986.
Online Mendelian Inheritance in Man (OMIM): 245660
McLean WH, Irvine AD, Hamill KJ, et al. (September 2003). "An unusual N-terminal deletion of the laminin alpha3a isoform leads to the chronic granulation tissue disorder laryngo-onycho-cutaneous syndrome". Hum. Mol. Genet. 12 (18): 2395–409. doi:10.1093/hmg/ddg234. PMID 12915477.

External links

Laryngo-onycho-cutaneous syndrome on MedlinePlus

Classification	D OMIM: 245660 MeSH: C537032

Diseases of collagen, laminin and other scleroproteins

Collagen disease

COL1:	Osteogenesis imperfecta (types I–IV) Ehlers–Danlos syndrome (types 1, 2, & 7)
COL2:	Hypochondrogenesis Achondrogenesis (type 2) Stickler syndrome Marshall syndrome Spondyloepiphyseal dysplasia congenita Spondyloepimetaphyseal dysplasia, (Strudwick type) Kniest dysplasia (Type II collagenopathy)
COL3:	Ehlers–Danlos syndrome (types 3 & 4) Sack–Barabas syndrome
COL4:	Alport syndrome
COL5:	Ehlers–Danlos syndrome (types 1 & 2)
COL6:	Bethlem myopathy (type 1) Ullrich congenital muscular dystrophy (type 1)
COL7:	Epidermolysis bullosa dystrophica Recessive dystrophic epidermolysis bullosa Bart syndrome Transient bullous dermolysis of the newborn
COL8:	Fuchs' dystrophy (type 1)
COL9:	Multiple epiphyseal dysplasia (types 2, 3, & 6)
COL10:	Schmid metaphyseal chondrodysplasia
COL11:	Weissenbacher–Zweymüller syndrome Otospondylomegaepiphyseal dysplasia (Type XI collagenopathy)
COL12:	Bethlem myopathy (type 2) Ullrich congenital muscular dystrophy (type 2)
COL17:	Bullous pemphigoid
COL18:	Knobloch syndrome

Laminin

Other

see also fibrous proteins

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