| Lymphomatoid papulosis | |
|---|---|
| Specialty | Dermatology  |
Lymphomatoid papulosis (LyP) is a rare skin disorder.
Prevalence
The overall prevalence rate of lymphomatoid papulosis is estimated at at least 1.2 cases per 1,000,000 population. This rare condition has only been studied in depth since 1968.
Presentation
It can appear very similar to anaplastic large cell lymphoma. Type "A" is CD30 positive, while type "B" is CD30 negative.
It has been described as "clinically benign but histologically malignant."
| A | Wedge-shaped clusters of large atypical lymphocytes that are CD30+, interspersed with a mixed inflammatory infiltrate of neutrophils, histiocytes, and eosinophils. |
|---|---|
| B | Similar to mycosis fungoides, with bandlike infiltrate and epidermotropism of smaller atypical lymphocytes that may be CD30-. |
| C | Similar to cutaneous anaplastic large-cell lymphoma, with larger clusters or sheets of large anaplastic CD30+ cells without the interspersed mixed infiltrate of Type A. |
| D | Similar to CD8+ epidermotropic cutaneous T-cell lymphoma, with large CD8+ and CD30+ lymphocytes that often stain with cytotoxic markers (TIA-1, granzyme, perforin). |
| E | Angioinvasive with small to large angiocentric CD30+ atypical lymphocytes that invade walls of small to medium vessels in dermis or subcutaneously. |
| F | Perifollicular infiltrates of CD30+ atypical cells with folliculotrophism with or without follicular mucinosis. |
Treatment
It may respond to methotrexate or PUVA.
Prognosis
It can evolve into lymphoma.
See also
- Cutaneous T-cell lymphoma
- Parapsoriasis
- Secondary cutaneous CD30+ large cell lymphoma
- List of cutaneous conditions
References
- Helen H. Wang; Lori Lach; Marshall E. Kadin (December 1992). "Epidemiology of Lymphomatoid Papulosis". The Cancer Journal. 70 (12): 2951–2957. doi:10.1002/1097-0142(19921215)70:12<2951::aid-cncr2820701236>3.0.co;2-7. PMID 1451079. S2CID 40452892.
- Macaulay WL (January 1968). "Lymphomatoid papulosis. A continuing self-healing eruption, clinically benign--histologically malignant". Arch Dermatol. 97 (1): 23–30. doi:10.1001/archderm.97.1.23. PMID 5634442.
- El Shabrawi-Caelen L, Kerl H, Cerroni L (April 2004). "Lymphomatoid papulosis: reappraisal of clinicopathologic presentation and classification into subtypes A, B, and C". Arch Dermatol. 140 (4): 441–7. doi:10.1001/archderm.140.4.441. PMID 15096372. Archived from the original on 2011-05-24.
- Neal S. Young; Stanton L. Gerson; Katherine A. High (2006). Clinical hematology. Elsevier Health Sciences. pp. 555–. ISBN 978-0-323-01908-8. Retrieved 14 May 2011.
- Maria Proytcheva (14 March 2011). Diagnostic Pediatric Hematopathology. Cambridge University Press. pp. 544–. ISBN 978-0-521-88160-9. Retrieved 15 May 2011.
- Hughey LC (2015). "Practical Management of CD30⁺ Lymphoproliferative Disorders". Dermatol Clin. 33 (4): 819–33. doi:10.1016/j.det.2015.05.013. PMID 26433852.
- Magro CM, Crowson AN, Morrison C, Merati K, Porcu P, Wright ED (April 2006). "CD8+ lymphomatoid papulosis and its differential diagnosis". American Journal of Clinical Pathology. 125 (4): 490–501. doi:10.1309/NNV4-L5G5-A0KF-1T06. PMID 16627259.
- Dalle S, Balme B, Thomas L (2006). "Lymphomatoid papulosis localized to the face". Dermatol. Online J. 12 (3): 9. doi:10.5070/D35DS430MG. PMID 16638423.
External links
| Classification | D |
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| Psoriasis |
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