Lyons House may refer to:
- in Australia
- Lyons House, a heritage listed house at 733 Port Hacking Rd, Dolans Bay, New South Wales.
- in Ireland
- Lyons House, County Kildare, Ireland
- in the United States (by state)
- Horace G. Lyons House, Berryton, Kansas, listed on the NRHP in Kansas
- Lyons House (Abbeville, Louisiana), listed on the NRHP in Louisiana
- Lyons House (Vinton, Louisiana), listed on the NRHP in Louisiana
- Benson H. Lyons House, Leesville, Louisiana, listed on the NRHP in Louisiana
- Joseph D. Lyons House, Sunderland, Maryland, listed on the NRHP in Maryland
- Byers-Lyons House, Pittsburgh, Pennsylvania, listed on the NRHP in Pennsylvania
- Frederick and Sallie Lyons House, Pleasanton, Texas, listed on the NRHP in Texas
- Oscar F. Lyons House, Peoa, Utah, listed on the NRHP in Utah
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