| MENTAL domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | MENTAL | ||||||||
| Pfam | PF10457 | ||||||||
| InterPro | IPR019498 | ||||||||
| PROSITE | PS51439 | ||||||||
| |||||||||
The MENTAL or MLN64 NH2-terminal domain is a membrane-spanning domain that is conserved in two late endosomal proteins in vertebrates, MLN64 and MENTHO. The domain is 170 amino acids long.
Current data indicates that this domain allows for dimerization between MLN64 and MENTHO molecules and with themselves. The domain may also direct cholesterol transport.
References
- Alpy F, Wendling C, Rio MC, Tomasetto C (2002). "MENTHO, a MLN64 Homologue Devoid of the START Domain". J. Biol. Chem. 277 (18): 50780–7. doi:10.1074/jbc.M208290200. PMID 12393907.
- Alpy F, Latchumanan VK, Kedinger V, Janoshazi A, Thiele C, Wendling C, Rio MC, Tomasetto C (2005). "Functional characterization of the MENTAL domain". J. Biol. Chem. 280 (18): 17945–52. doi:10.1074/jbc.M500723200. PMID 15718238.