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MTO1
Identifiers
Aliases	MTO1, COXPD10, CGI-02, mitochondrial tRNA translation optimization 1
External IDs	OMIM: 614667; MGI: 1915541; HomoloGene: 5876; GeneCards: MTO1; OMA:MTO1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6q13 Start 73,461,578 bp End 73,509,236 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 E1 Start 78,355,490 bp End 78,382,630 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium sperm endothelial cell granulocyte right lobe of liver epithelium of nasopharynx Achilles tendon gonad kidney tubule right ventricle Top expressed in proximal tubule spermatocyte medullary collecting duct right kidney quadriceps femoris muscle fetal liver hematopoietic progenitor cell triceps surae gastrocnemius muscle tibialis anterior muscle vastus lateralis muscle More reference expression data BioGPS n/a
Gene ontology Molecular function flavin adenine dinucleotide binding RNA binding Cellular component mitochondrion Biological process tRNA methylation mitochondrial tRNA wobble uridine modification tRNA processing tRNA wobble uridine modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25821 68291 Ensembl ENSG00000135297 ENSMUSG00000032342 UniProt Q9Y2Z2 Q923Z3 RefSeq (mRNA) NM_001123226 NM_012123 NM_133645 NM_026658 RefSeq (protein) NP_001116698 NP_036255 NP_598400 NP_080934 Location (UCSC) Chr 6: 73.46 – 73.51 Mb Chr 9: 78.36 – 78.38 Mb PubMed search
Wikidata
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Protein MTO1 homolog, mitochondrial is a protein that in humans is encoded by the MTO1 gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000135297 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000032342 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Li X, Li R, Lin X, Guan MX (Jul 2002). "Isolation and characterization of the putative nuclear modifier gene MTO1 involved in the pathogenesis of deafness-associated mitochondrial 12 S rRNA A1555G mutation". J Biol Chem. 277 (30): 27256–64. doi:10.1074/jbc.M203267200. PMID 12011058.
6. "Entrez Gene: MTO1 mitochondrial translation optimization 1 homolog (S. cerevisiae)".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Bykhovskaya Y, Mengesha E, Wang D, et al. (2005). "Phenotype of non-syndromic deafness associated with the mitochondrial A1555G mutation is modulated by mitochondrial RNA modifying enzymes MTO1 and GTPBP3". Mol. Genet. Metab. 83 (3): 199–206. doi:10.1016/j.ymgme.2004.07.009. PMID 15542390.
• Krull M, Brosius J, Schmitz J (2005). "Alu-SINE exonization: en route to protein-coding function". Mol. Biol. Evol. 22 (8): 1702–11. doi:10.1093/molbev/msi164. PMID 15901843.

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