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Malotilate

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Chemical compound Pharmaceutical compound
Malotilate
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration		By mouth
ATC code
  • none
Legal status
Legal status
  • Experimental(?)
Identifiers
IUPAC name
  • diisopropyl 1,3-dithiol-2-ylidenemalonate
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.056.334 Edit this at Wikidata
Chemical and physical data
FormulaC12H16O4S2
Molar mass288.38 g·mol
3D model (JSmol)
SMILES
  • CC(C)OC(=O)C(=C1SC=CS1)C(=O)OC(C)C
InChI
  • InChI=1S/C12H16O4S2/c1-7(2)15-10(13)9(11(14)16-8(3)4)12-17-5-6-18-12/h5-8H,1-4H3
  • Key:YPIQVCUJEKAZCP-UHFFFAOYSA-N
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Malotilate (INN) is a drug that has been used in studies for the treatment of liver disease. It has been shown to facilitate liver regeneration in rats.

References

  1. Niwano Y, Katoh M, Uchida M, Sugimoto T (1986). "Acceleration of Liver Regeneration by Malotilate in Partially Hepatectomized Rats". Japanese Journal of Pharmacology. 40 (3): 411–415. doi:10.1254/jjp.40.411. PMID 2423727.
  • Bührer M, Le Cotonnec JY, Wermeille M, Bircher J (1986). "Treatment of liver disease with malotilate. A pharmacokinetic and pharmacodynamic phase II study in cirrhosis". Eur. J. Clin. Pharmacol. 30 (4): 407–16. doi:10.1007/BF00607952. PMID 3743616. S2CID 19898827.
  • Siegers CP, Pauli V, Korb G, Younes M (August 1986). "Hepatoprotection by malotilate against carbon tetrachloride-alcohol-induced liver fibrosis". Agents Actions. 18 (5–6): 600–3. doi:10.1007/BF01964970. PMID 3766314. S2CID 3213262.
  • Younes M, Siegers CP (May 1985). "Effect of malotilate on paracetamol-induced hepatotoxicity". Toxicol. Lett. 25 (2): 143–6. doi:10.1016/0378-4274(85)90074-8. PMID 4002245.


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