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Mammalian CPEB3 ribozyme

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Ribozyme
Mammalian CPEB3 ribozyme
Predicted secondary structure and sequence conservation of CPEB3_ribozyme
Identifiers
SymbolCPEB3_ribozyme
RfamRF00622
Other data
RNA typeGene; ribozyme
Domain(s)Eukaryota
SOSO:0000374
PDB structuresPDBe

The mammalian CPEB3 ribozyme is a self cleaving non-coding RNA located in the second intron of the CPEB3 gene which belongs to a family of genes regulating messenger RNA polyadenylation. This ribozyme is highly conserved and found only in mammals. The CPEB3 ribozyme is structurally and biochemically related to the human hepatitis delta virus ribozyme. Other HDV-like ribozymes have been identified and confirmed to be active in vitro in a number of eukaryotes.

References

  1. ^ Salehi-Ashtiani K, Luptak A, Litovchick A, Szostak JW (2006). "A genomewide search for ribozymes reveals an HDV-like sequence in thehuman CPEB3 gene". Science. 313 (5794): 1788–1792. Bibcode:2006Sci...313.1788S. doi:10.1126/science.1129308. PMID 16990549. S2CID 43309772.
  2. Chadalavada DM, Gratton EA, Bevilacqua PC (2010). "The Human HDV-like CPEB3 Ribozyme Is Intrinsically Fast-Reacting". Biochemistry. 49 (25): 5321–5330. doi:10.1021/bi100434c. PMC 2890282. PMID 20524672.
  3. Webb, CH; Riccitelli, NJ; Ruminski, DJ; Lupták, A (Nov 13, 2009). "Widespread occurrence of self-cleaving ribozymes". Science. 326 (5955): 953. Bibcode:2009Sci...326..953W. doi:10.1126/science.1178084. PMC 3159031. PMID 19965505.

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