Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase

(Redirected from Mannosidase II)

Mannosyl-oligosaccharide 1,3-1,6-α-mannosidase

Identifiers

3.2.1.114

82047-77-6

Alt. names

mannosidase II, exo-1,3-1,6-α-mannosidase, α-D-mannosidase II, α-mannosidase II, α-3,6-mannosidase, GlcNAc transferase I-dependent α1,3mannosidase, Golgi α-mannosidase II, ManII, 1,3(1,6)-α-D-mannosidase, 1,3-(1,6-)mannosyl-oligosaccharide α-D-mannohydrolase

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Mannosyl-oligosaccharide 1,3-1,6-α-mannosidase, also known as Golgi α-mannosidase II, is an enzyme with systematic name (1→3)-(1→6)-mannosyl-oligosaccharide α-D-mannohydrolase. It catalyses the hydrolysis of the terminal (1→3)- and (1→6)-linked α-D-mannose residues in the mannosyl-oligosaccharide Man₅(GlcNAc)₃.

This enzyme is involved in the synthesis of glycoproteins. It is a key enzyme of N-linked glycan processing and is inhibited by small molecule swainsonine.

References

Harpaz N, Schachter H (May 1980). "Control of glycoprotein synthesis. Processing of asparagine-linked oligosaccharides by one or more rat liver Golgi α-D-mannosidases dependent on the prior action of UDP-N-acetylglucosamine: α-D-mannoside β 2-N-acetylglucosaminyltransferase I". The Journal of Biological Chemistry. 255 (10): 4894–902. PMID 6445359.
Tulsiani DR, Hubbard SC, Robbins PW, Touster O (Apr 1982). "α-D-Mannosidases of rat liver Golgi membranes. Mannosidase II is the GlcNAcMAN5-cleaving enzyme in glycoprotein biosynthesis and mannosidases Ia and IB are the enzymes converting Man₉ precursors to Man₅ intermediates". The Journal of Biological Chemistry. 257 (7): 3660–8. PMID 7061502.
Tulsiani DR, Opheim DJ, Touster O (May 1977). "Purification and characterization of α-D-mannosidase from rat liver Golgi membranes". The Journal of Biological Chemistry. 252 (10): 3227–33. PMID 863880.
Athanasopoulos VI, Niranjan K, Rastall RA (Mar 2005). "The production, purification and characterisation of two novel α-D-mannosidases from Aspergillus phoenicis". Carbohydrate Research. 340 (4): 609–17. doi:10.1016/j.carres.2005.01.005. PMID 15721331.
van den Elsen JM, Kuntz DA, Rose DR (2001). "Structure of Golgi α-mannosidase II: a target for inhibition of growth and metastasis of cancer cells". The EMBO Journal. 20 (12): 3008–3017. doi:10.1093/emboj/20.12.3008. PMC 150216. PMID 11406577.

External links

Mannosyl-oligosaccharide+1,3-1,6-α-mannosidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Hydrolase: sugar hydrolases (EC 3.2)

3.2.1: Glycoside hydrolases

Disaccharidase	Sucrase/Sucrase-isomaltase/Invertase Maltase Trehalase Lactase
Glucosidases	Cellulase Alpha-glucosidase Acid Neutral AB Neutral C Beta-glucosidase cytosolic Debranching enzyme
Other	Amylase Alpha-amylase Chitinase Lysozyme Neuraminidase NEU1 NEU2 NEU3 NEU4 Bacterial neuraminidase Viral neuraminidase Galactosidases Alpha Beta alpha-Mannosidase Glucuronidase Klotho Hyaluronidase Pullulanase Glucosylceramidase lysosomal non-lysosomal Galactosylceramidase Alpha-N-acetylgalactosaminidase NAGA Alpha-N-acetylglucosaminidase Fucosidase Hexosaminidase HEXA HEXB Iduronidase Maltase-glucoamylase Heparanase HPSE2

3.2.2: Hydrolysing
N-Glycosyl compounds

DNA glycosylases: Oxoguanine glycosylase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Portal:

Biology

Category:

EC 3.2.1