Manuel Rodríguez may refer to:
Sports
- Manolete (Manuel Rodríguez Sánchez, 1917–1947), Spanish bullfighter
- Manuel Rodríguez Barros (1926-1997), Spanish cyclist
- Manuel Rodríguez (footballer) (1938–2018), Chilean footballer
- Manuel Rodríguez Navarro (born 1969), Spanish wheelchair basketball player
- Manuel Cristian Rodríguez (boxer) (born 1973), Argentine boxer
- Manuel Rodríguez (first baseman) (born 1985), Panamanian baseball player
- Manu Rodríguez (born 1991), Spanish basketball player
- Manuel Rodríguez (pitcher) (born 1996), Mexican baseball player
- Manuel Rodríguez (tennis), Chilean tennis player
Others
- Manuel Rodríguez Erdoíza (1785–1818), Chilean lawyer and guerrilla leader
- Manuel Rodríguez Lozano (1896–1971), Mexican painter
- Manuel Rodríguez Orellana (born 1948), Puerto Rican legal scholar, lawyer, lecturer, columnist, published poet and political leader
- Manuel Rodríguez Ramos (born 1908), Puerto Rican writer, law professor and Secretary of Justice of Puerto Rico
- Manuel Rodríguez Torices (1788–1816), Neogranadine statesman, lawyer, journalist, and Precursor of the Independence of Colombia
- Manuel Rodríguez Gómez (1928–2006), American neurologist most noted for his work on tuberous sclerosis, a rare genetic disorder
- Manuel Rodríguez Cuadros (born 1949), Peruvian diplomat and presidential candidate
Other uses
- Manuel Rodríguez Patriotic Front, left-wing guerrilla movement in Chile
- Manuel Rodriguez Island, an island in the Patagonian Archipelago in Magallanes y la Antártica Chilena Region, Chile
- Manuel Rodríguez (TV series), a 2010 Chilean telenovela broadcast in Chilevisión, based on the Chilean guerrilla Manuel Rodríguez Erdoiza
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