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MicroRNA 4727

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Non-coding RNA in the species Homo sapiens
MIR4727
Identifiers
AliasesMIR4727, mir-4727, microRNA 4727
External IDsGeneCards: MIR4727; OMA:MIR4727 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)
Chromosome 17 (human)Genomic location for MIR4727Genomic location for MIR4727
Band17q12Start38,825,838 bp
End38,825,892 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • bone marrow

  • putamen

  • blood

  • stomach

  • gastrocnemius muscle

  • monocyte

  • islet of Langerhans

  • spleen

  • human kidney

  • anterior cingulate cortex
    n/a
More reference expression data
BioGPS
n/a
Orthologs
SpeciesHumanMouse
Entrez

100616416

n/a

Ensembl

ENSG00000274054

n/a

UniProt

n
a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)Chr 17: 38.83 – 38.83 Mbn/a
PubMed searchn/a
Wikidata
View/Edit Human

MicroRNA 4727 is a microRNA that in humans is produced by the MIR4727 gene.

Function

microRNAs (miRNAs) are short (20–24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. .

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000274054 – Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Entrez Gene: MicroRNA 4727". Retrieved 2017-10-30.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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