Mikolajczak or Mikołajczak is a surname. Notable people with the surname include:
- Celina Mikolajczak, American battery engineer and amateur astronomer
- Christian Mikolajczak (born 1981), German footballer
- Detlef Mikolajczak (born 1964), German footballer
- Martyna Mikołajczak (born 1991), Polish rower
- Tomasz Mikołajczak (born 1987), Polish footballer
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