NEST (software) - Misplaced Pages

Not to be confused with Novell Embedded Systems Technology.

NEST (Neural Simulation Tool)

Original author(s)	Markus Diesmann, Marc-Oliver Gewaltig, Abigail Morrison, Hans Ekkehard Plesser
Developer(s)	The NEST Initiative
Initial release	1 August 2004 (2004-08-01)

Stable release	3.3 / 22 March 2023; 20 months ago (2023-03-22)

Repository	github.com/nest/nest-simulator
Written in	C++, Python, Cython
Operating system	cross-platform
Available in	English
Type	Computational Neuroscience
License	GPLv2+
Website	www.nest-simulator.org

NEST is a simulation software for spiking neural network models, including large-scale neuronal networks. NEST was initially developed by Markus Diesmann and Marc-Oliver Gewaltig and is now developed and maintained by the NEST Initiative.

Modeling philosophy

A NEST simulation tries to follow the logic of an electrophysiological experiment that takes place inside a computer with the difference, that the neural system to be investigated must be defined by the experimenter.

The neural system is defined by a possibly large number of neurons and their connections. In a NEST network, different neuron and synapse models can coexist. Any two neurons can have multiple connections with different properties. Thus, the connectivity can in general not be described by a weight or connectivity matrix but rather as an adjacency list.

To manipulate or observe the network dynamics, the experimenter can define so-called devices which represent the various instruments (for measuring and stimulation) found in an experiment. These devices write their data either to memory or to file.

NEST is extensible and new models for neurons, synapses, and devices can be added.

Example

The following example simulates spiking activity in a sparse random network with recurrent excitation and inhibition

The figure shows the spiking activity of 50 neurons as a raster plot. Time increases along the horizontal axis, neuron id increases along the vertical axis. Each dot corresponds to a spike of the respective neuron at a given time. The lower part of the figure shows a histogram with the mean firing-rate of the neurons.

import nest
import nest.raster_plot
J_ex = 0.1  # excitatory weight
J_in = -0.5  # inhibitory weight
p_rate = 20000.0  # external Poisson rate
neuron_params= {"C_m": 1.0, "tau_m": 20.0, "t_ref": 2.0,
                "E_L": 0.0, "V_reset": 0.0, "V_m": 0.0, "V_th": 20.0}
# Set parameters of neurons and devices
nest.SetDefaults("iaf_psc_delta", neuron_params)
nest.SetDefaults("poisson_generator", {"rate": p_rate})
nest.SetDefaults("spike_detector", {"withtime": True, "withgid": True})
# Create neurons and devices
nodes_ex = nest.Create("iaf_psc_delta", 10000)
nodes_in = nest.Create("iaf_psc_delta", 2500)
noise = nest.Create("poisson_generator")
espikes = nest.Create("spike_detector")
# Configure synapse models
nest.CopyModel("static_synapse", "excitatory", {"weight": J_ex, "delay": 1.5})
nest.CopyModel("static_synapse", "inhibitory", {"weight": J_in, "delay": 1.5})
# Connect the random net and instrument it with the devices
nest.Connect(nodes_ex, nodes_ex+nodes_in, {"rule": 'fixed_indegree', "indegree": 1000}, "excitatory")
nest.Connect(nodes_in, nodes_ex+nodes_in, {"rule": 'fixed_indegree', "indegree": 250}, "inhibitory")
nest.Connect(noise, nodes_ex + nodes_in, syn_spec="excitatory")
nest.Connect(nodes_ex, espikes)
# Simulate for 100. ms
nest.Simulate(100.0)
# Plot results
nest.raster_plot.from_device(espikes, hist=True)
nest.raster_plot.show()

Features

Neuron models

Integrate-and-fire models with different types of synaptic currents or potentials
Integrate-and-fire models with conductance based synapses
Single compartment Hodgkin–Huxley models
Adaptive Exponential Integrate and Fire neuron (AdEx)
MAT2 neuron model

Network models

Random neural network
Topological networks
Data-driven network models

Synapse models

Static synapses with homogeneous or heterogeneous weight and delay.
Spike-timing-dependent plasticity
Short-term plasticity (Tsodyks & Markram synapses)
Neuromodulated synapses, using Dopamine.

Device models

Spike detector
Multimeter for potentials, currents, etc.
AC, DC, and step current generators
Noise generators (Poisson, Gauss, Gamma)
Spike generators for replay of spikes

Accuracy

NEST aims at high accuracy and precision of its simulations
Each neuron model has its appropriate solver and many models have unit tests.
If possible, exact integration is used.
By default, spikes fall onto the grid, defined by the simulation time-step. Some models support spike-exchange in continuous time.

Parallel and distributed simulation

Support for multi-threaded simulation, using OpenMP or POSIX Threads.
Support for hybrid multi-threaded and distributed simulation.
Parallelization is handled semi-automatically by NEST's simulation kernel.
Supra-linear to linear scaling for up to 10000 cores.

Interoperability

Interface to the Multi Simulator Coordinator, developed by the INCF.
Interface to the simulator independent simulation language PyNN.

History

NEST development was started in 1993 by Markus Diesmann and Marc-Oliver Gewaltig at the Ruhr University Bochum, Bochum, Germany and the Weizmann Institute of Science in Rehovot, Israel. At this time, the simulator was called SYNOD and simulations were defined in a stack based simulation language, called SLI.

In 2001, the software changed its name from SYNOD to NEST. Until 2004, NEST was exclusively developed and used by the founding members of the NEST Initiative. The first public release appeared in summer 2004. Since then, NEST was released regularly, about once or twice per year.

Since 2007, NEST supports hybrid parallelism, using POSIX threads and MPI.

In 2008, the stack-based simulation language SLI was superseded by a modern Python interface, however, the old simulation language is still used internally. At the same time, the simulator independent specification language PyNN was developed with support for NEST. In 2012, the NEST Initiative changed the license from the proprietary NEST License to GNU GPL V2 or later.

User interfaces

NEST primary user interface is PyNEST, a Python package that controls the NEST simulation kernel. PyNEST aims at easy usability and seamless interaction with Python and its libraries.
PyNN is a simulator independent language for neural simulations, which supports NEST as well as BRIAN, NEURON, as well as neuromorphic hardware.
NEST also maintains its own simulation language interpreter (SLI), which understands a simple Stack-oriented programming language that is influenced by PostScript.

References

Brunel, Nicolas (2000). "Dynamics of Sparsely Connected Networks of Excitatory and Inhibitory Spiking Neurons". Journal of Computational Neuroscience. 8 (3): 183–208. doi:10.1023/A:1008925309027. PMID 10809012. S2CID 1849650.
Henker, S.; Partzsch, J.; Schüffny, R. (2012). "Accuracy evaluation of numerical methods used in state-of-the-art simulators for spiking neural networks". Journal of Computational Neuroscience. 32 (2): 309–326. doi:10.1007/s10827-011-0353-9. PMID 21837455. S2CID 254601151.
Rotter, Stefan; Diesmann, Markus (1999). "Exact digital simulation of time-invariant linear systems with applications to neuronal modeling". Biological Cybernetics. 81 (5–6): 381–402. doi:10.1007/s004220050570. PMID 10592015. S2CID 8124866.
Morrison, Abigail; Straube, Sirko; Plesser, Hans Ekkehard; Diesmann, Markus (2007). "Exact Subthreshold Integration with Continuous Spike Times in Discrete-Time Neural Network Simulations". Neural Computation. 19 (1): 47–79. doi:10.1162/neco.2007.19.1.47. PMID 17134317. S2CID 8517223.
^ Plesser, Hans E.; Eppler, Jochen M.; Morrison, Abigail; Diesmann, Markus; Gewaltig, Marc-Oliver (2007). "Efficient Parallel Simulation of Large-Scale Neuronal Networks on Clusters of Multiprocessor Computers". Euro-Par 2007 Parallel Processing. Lecture Notes in Computer Science. Vol. 4641. pp. 672–681. doi:10.1007/978-3-540-74466-5_71. ISBN 978-3-540-74465-8.
Djurfeldt, Mikael; Hjorth, Johannes; Eppler, Jochen M.; Dudani, Niraj; Helias, Moritz; Potjans, Tobias C.; Bhalla, Upinder S.; Diesmann, Markus; Hellgren Kotaleski, Jeanette; Ekeberg, Örjan (2010). "Run-Time Interoperability Between Neuronal Network Simulators Based on the MUSIC Framework". Neuroinformatics. 8 (1): 43–60. doi:10.1007/s12021-010-9064-z. PMC 2846392. PMID 20195795.
NEST - A brain simulator (video). Bernstein Network. 2012-07-11 – via YouTube.
Eppler, Jochen M.; Helias, M.; Muller, E.; Diesmann, M.; Gewaltig, M. O. (2008). "PyNEST: A convenient interface to the NEST simulator". Frontiers in Neuroinformatics. 2: 12. doi:10.3389/neuro.11.012.2008. PMC 2636900. PMID 19198667.
Davison, A. P.; Brüderle, D.; Eppler, J.; Kremkow, J.; Muller, E.; Pecevski, D.; Perrinet, L.; Yger, P. (2009). "PyNN: A Common Interface for Neuronal Network Simulators". Frontiers in Neuroinformatics. 2: 11. doi:10.3389/neuro.11.011.2008. PMC 2634533. PMID 19194529.

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