NeuroD, also called Beta2, is a basic helix-loop-helix transcription factor expressed in certain parts of brain, beta pancreatic cells and enteroendocrine cells. It is involved in the differentiation of nervous system and development of pancreas. It heterodimerizes with the products of E2A gene and controls the transcription of a variety of genes by identifying and binding E boxes in their promoter region. In rodents NeuroD is involved in the development of the retina.
In mammals there are two types of this factor:
References
- Gu, Chunyan; Stein, Gretchen H.; Pan, Ning; Goebbels, Sandra; Hörnberg, Hanna; Nave, Klaus-Armin; Herrera, Pedro; White, Peter; Kaestner, Klaus H.; Sussel, Lori; Lee, Jacqueline E. (7 April 2010). "Pancreatic β Cells Require NeuroD to Achieve and Maintain Functional Maturity". Cell Metabolism. 11 (4): 298–310. doi:10.1016/j.cmet.2010.03.006. ISSN 1550-4131. PMC 2855640. PMID 20374962.
- Morrow, E.M.; Furukawa, T.; Lee, J.E.; Cepko, C.L. (1 January 1999). "NeuroD regulates multiple functions in the developing neural retina in rodent". Development. 126 (1): 23–36. doi:10.1242/dev.126.1.23. PMID 9834183. Retrieved 1 March 2022.
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