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NOXO1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2L73
Identifiers
Aliases	NOXO1, P41NOX, P41NOXA, P41NOXB, P41NOXC, SH3PXD5, SNX28, NADPH oxidase organizer 1
External IDs	OMIM: 611256; MGI: 1919143; HomoloGene: 12418; GeneCards: NOXO1; OMA:NOXO1 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16p13.3 Start 1,978,917 bp End 1,984,192 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17 A3.3|17 12.49 cM Start 24,915,208 bp End 24,919,503 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon gonad testicle rectum appendix olfactory zone of nasal mucosa right hemisphere of cerebellum mucosa of sigmoid colon right lobe of liver left testis Top expressed in Paneth cell crypt of lieberkuhn of small intestine spermatocyte large intestine colon left colon ileum spermatid jejunum intestinal villus More reference expression data BioGPS n/a
Gene ontology Molecular function enzyme binding superoxide-generating NADPH oxidase activator activity protein binding phospholipid binding identical protein binding lipid binding phosphatidylinositol binding Cellular component plasma membrane NADPH oxidase complex membrane intracellular anatomical structure Biological process regulation of respiratory burst extracellular matrix disassembly positive regulation of catalytic activity regulation of hydrogen peroxide metabolic process superoxide metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 124056 71893 Ensembl ENSG00000196408 ENSMUSG00000019320 UniProt Q8NFA2 Q8VCM2 RefSeq (mRNA) NM_001267721 NM_144603 NM_172167 NM_172168 NM_027988 NM_001357836 RefSeq (protein) NP_001254650 NP_653204 NP_751907 NP_751908 NP_082264 NP_001344765 Location (UCSC) Chr 16: 1.98 – 1.98 Mb Chr 17: 24.92 – 24.92 Mb PubMed search
Wikidata
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NADPH oxidase organizer 1 is an enzyme that in humans is encoded by the NOXO1 gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000196408 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000019320 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: NOXO1 NADPH oxidase organizer 1".

Further reading

• Bánfi B, Clark RA, Steger K, Krause KH (2003). "Two novel proteins activate superoxide generation by the NADPH oxidase NOX1". J. Biol. Chem. 278 (6): 3510–3. doi:10.1074/jbc.C200613200. PMID 12473664.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Geiszt M, Lekstrom K, Witta J, Leto TL (2003). "Proteins homologous to p47phox and p67phox support superoxide production by NAD(P)H oxidase 1 in colon epithelial cells". J. Biol. Chem. 278 (22): 20006–12. doi:10.1074/jbc.M301289200. PMID 12657628.
• Takeya R, Ueno N, Kami K, et al. (2003). "Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases". J. Biol. Chem. 278 (27): 25234–46. doi:10.1074/jbc.M212856200. PMID 12716910.
• Cheng G, Lambeth JD (2004). "NOXO1, regulation of lipid binding, localization, and activation of Nox1 by the Phox homology (PX) domain". J. Biol. Chem. 279 (6): 4737–42. doi:10.1074/jbc.M305968200. PMID 14617635.
• Cheng G, Ritsick D, Lambeth JD (2004). "Nox3 regulation by NOXO1, p47phox, and p67phox". J. Biol. Chem. 279 (33): 34250–5. doi:10.1074/jbc.M400660200. PMID 15181005.
• Bánfi B, Malgrange B, Knisz J, et al. (2004). "NOX3, a superoxide-generating NADPH oxidase of the inner ear". J. Biol. Chem. 279 (44): 46065–72. doi:10.1074/jbc.M403046200. PMID 15326186.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ueno N, Takeya R, Miyano K, et al. (2005). "The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activators". J. Biol. Chem. 280 (24): 23328–39. doi:10.1074/jbc.M414548200. PMID 15824103.
• Cheng G, Lambeth JD (2005). "Alternative mRNA splice forms of NOXO1: differential tissue expression and regulation of Nox1 and Nox3". Gene. 356: 118–26. doi:10.1016/j.gene.2005.03.008. PMID 15949904.
• Park HS, Park D, Bae YS (2006). "Molecular interaction of NADPH oxidase 1 with betaPix and Nox Organizer 1". Biochem. Biophys. Res. Commun. 339 (3): 985–90. doi:10.1016/j.bbrc.2005.11.108. PMID 16329988.
• Takeya R, Taura M, Yamasaki T, et al. (2006). "Expression and function of Noxo1gamma, an alternative splicing form of the NADPH oxidase organizer 1". FEBS J. 273 (16): 3663–77. doi:10.1111/j.1742-4658.2006.05371.x. PMID 16911517. S2CID 701568.
• Yamamoto A, Kami K, Takeya R, Sumimoto H (2007). "Interaction between the SH3 domains and C-terminal proline-rich region in NADPH oxidase organizer 1 (Noxo1)". Biochem. Biophys. Res. Commun. 352 (2): 560–5. doi:10.1016/j.bbrc.2006.11.060. PMID 17126813.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human NADPH oxidase organizer 1

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