Pharmaceutical compound
 | |
| Combination of | |
|---|---|
| Neomycin | Antibiotic |
| Polymyxin B | Antibiotic |
| Hydrocortisone | Glucocorticoid |
| Clinical data | |
| Trade names | Otosporin, Cortisporin, others |
| AHFS/Drugs.com | FDA Professional Drug Information |
| Routes of administration | Ear drop |
| ATC code |
|
| Legal status | |
| Legal status |
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| Identifiers | |
| CAS Number | |
| KEGG | |
Neomycin/polymyxin B/hydrocortisone, sold under the brand Otosporin among others, is a medication used to treat otitis externa (swimmer's ear) and certain eye disorders. It consists of the antibiotics neomycin and polymyxin B, and the steroid hydrocortisone. It is used as an ear drop or eye drop.
The most common side effects include itchiness and a skin rash. Other side effects may include dizziness, hives, anaphylaxis, hearing loss, and headache. Safety in pregnancy and breastfeeding is unclear. The antibiotics work by killing specific types of bacteria while the steroids work by decreasing inflammation.
The combination was approved for medical use in the United States in 1964. In 2022, it was the 296th most commonly prescribed medication in the United States, with more than 400,000 prescriptions.
History
Cortisporin was developed by Glaxo Wellcome and was approved by the US Food and Drug Administration in 1975. In 1997, the rights were sold to Monarch Pharmaceuticals, a division of King Pharmaceuticals. In 2007, King sold it to JHP Pharmaceuticals. Par Pharmaceutical acquired JHP in 2014. In 2015, Endo International purchased Par.
Society and culture
Economics
In 2015, the price was $100, and in 2016, it reportedly was selling for $195. A generic version is priced at $144. The drug is owned by Dublin, Ireland-based Endo International..
References
- "Neomycin and Polymyxin B Sulfates and Hydrocortisone- neomycin sulfate, polymyxin b sulfate and hydrocortisone solution". DailyMed. 22 April 2019. Retrieved 22 June 2022.
- ^ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 1164. ISBN 9780857113382.
- ^ "Neomycin, Polymyxin B, Hydrocortisone Ophthalmic Suspension - FDA prescribing information, side effects and uses". Drugs.com. Retrieved 19 April 2019.
- ^ "Hydrocortisone/neomycin/polymyxin b otic Side Effects in Detail". Drugs.com. Retrieved 19 April 2019.
- "Hydrocortisone / neomycin / polymyxin b otic Use During Pregnancy". Drugs.com. Retrieved 19 April 2019.
- "DailyMed - neomycin sulfate, polymyxin b sulfate and hydrocortisone solution". dailymed.nlm.nih.gov. Retrieved 19 April 2019.
- "The Top 300 of 2022". ClinCalc. Archived from the original on 30 August 2024. Retrieved 30 August 2024.
- "Neomycin; Polymyxin B; Hydrocortisone Drug Usage Statistics, United States, 2013 - 2022". ClinCalc. Retrieved 30 August 2024.
- ^ David L (4 February 2016). "Martin Shkreli isn't alone in ripping off patients with crazy drug prices". Los Angeles Times. Retrieved 5 February 2016.
