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Neopluramycin

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Neopluramycin
Names
IUPAC name 6-{2--8--11-hydroxy-5-methyl-4,7,12-trioxo-7,12-dihydro-4H-naphthochromen-10-yl}-4-(dimethylamino)-2,4-dimethyltetrahydro-2H-pyran-3-yl acetate
Identifiers
CAS Number
3D model (JSmol)
ChEMBL
ChemSpider
PubChem CID
InChI
  • InChI=1S/C41H50N2O10/c1-12-18(2)28-16-27(45)31-19(3)13-25-33(39(31)53-28)38(49)34-32(37(25)48)23(29-15-26(42(8)9)35(46)20(4)50-29)14-24(36(34)47)30-17-41(7,43(10)11)40(21(5)51-30)52-22(6)44/h12-14,16,20-21,26,29-30,35,40,46-47H,15,17H2,1-11H3/b18-12+Key: FGTVZROOHPSJNZ-LDADJPATSA-N
SMILES
  • C/C=C(\C)/C1=CC(=O)C2=C(O1)C3=C(C=C2C)C(=O)C4=C(C3=O)C(=C(C=C4C5CC(C(C(O5)C)O)N(C)C)C6CC(C(C(O6)C)OC(=O)C)(C)N(C)C)O
Properties
Chemical formula C41H50N2O10
Molar mass 730.855 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references
Chemical compound

Neopluramycin is an antibiotic that inhibits nucleic acid synthesis. It has been isolated from the cultured broth of a strain of Streptomyces pluricolorescens as orange crystals, and analytical data and molecular weight determination are consistent with the empirical formula C
41H
50N
2O
10.

Neopluramycin resembles pluramycin A, but is differentiated by its antibacterial spectrum, toxicity, thin-layer chromatography, and infrared absorption spectrum.

Neopluramycin inhibits growth of Gram-positive bacteria, leukemia L-1210 in mice and Yoshida rat sarcoma cells in tissue culture.

References

  1. ^ Kondo S, Wakashiro T, Hamada M, Maeda K, Takeuchi T (July 1970). "Isolation and characterization of a new antibiotic, neopluramycin". The Journal of Antibiotics. 23 (7): 354–9. doi:10.7164/antibiotics.23.354. PMID 5460277.
  2. Tsukada I, Hamada M, Umezawa H, Hori M, Hayashi H (March 1971). "Neopluramycin, an inhibitor of nucleic acid synthesis". The Journal of Antibiotics. 24 (3): 189–96. doi:10.7164/antibiotics.24.189. PMID 4323924.


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