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Nibrozetone

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Pharmaceutical compound
Nibrozetone
Clinical data
Other namesRrx-001
Identifiers
IUPAC name
  • 2-bromo-1-(3,3-dinitroazetidin-1-yl)ethanone
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
Chemical and physical data
FormulaC5H6BrN3O5
Molar mass268.023 g·mol
3D model (JSmol)
SMILES
  • C1C(CN1C(=O)CBr)((=O))(=O)
InChI
  • InChI=InChI=1S/C5H6BrN3O5/c6-1-4(10)7-2-5(3-7,8(11)12)9(13)14/h1-3H2
  • Key:JODKFOVZURLVTG-UHFFFAOYSA-N

Nibrozetone is an investigational new drug that is being evaluated by EpicentRx for the treatment of oral mucositis in head and neck cancer patients. It is a small molecule that combines direct inhibition of the NLRP3 inflammasome, induction of NRF2, and release of nitric oxide under hypoxic conditions. It has received Fast Track designation from the FDA for severe oral mucositis in head and neck cancer patients.

References

  1. Oronsky B, Takahashi L, Gordon R, Cabrales P, Caroen S, Reid T (2023). "RRx-001: a chimeric triple action NLRP3 inhibitor, Nrf2 inducer, and nitric oxide superagonist". Frontiers in Oncology. 13: 1204143. doi:10.3389/fonc.2023.1204143. PMC 10258348. PMID 37313460.
  2. Jayabalan N, Oronsky B, Cabrales P, Reid T, Caroen S, Johnson AM, et al. (April 2023). "A Review of RRx-001: A Late-Stage Multi-Indication Inhibitor of NLRP3 Activation and Chronic Inflammation". Drugs. 83 (5): 389–402. doi:10.1007/s40265-023-01838-z. PMC 10015535. PMID 36920652.
  3. Ryan C (30 March 2023). "FDA Grants Fast Track Designation to RRx-001 for Severe Oral Mucositis in Head and Neck Cancer". OncLive.


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