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OSBPL11
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D9X
Identifiers
Aliases	OSBPL11, ORP-11, ORP11, OSBP12, TCCCIA00292, oxysterol binding protein like 11
External IDs	OMIM: 606739; MGI: 2146553; HomoloGene: 23385; GeneCards: OSBPL11; OMA:OSBPL11 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3q21.2 Start 125,528,858 bp End 125,595,497 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16|16 B3 Start 33,005,441 bp End 33,063,682 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in biceps brachii Skeletal muscle tissue of biceps brachii vastus lateralis muscle thoracic diaphragm deltoid muscle gastrocnemius muscle monocyte tibialis anterior muscle Skeletal muscle tissue of rectus abdominis secondary oocyte Top expressed in cumulus cell gastrula primary oocyte secondary oocyte stroma of bone marrow ureter primitive streak Rostral migratory stream zygote lens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function lipid binding sterol transporter activity sterol binding Cellular component endosome membrane late endosome membrane nucleoplasm Golgi apparatus cytosol intracellular membrane-bounded organelle Biological process lipid transport positive regulation of sequestering of triglyceride fat cell differentiation sterol transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 114885 106326 Ensembl ENSG00000144909 ENSMUSG00000022807 UniProt Q9BXB4 Q8CI95 RefSeq (mRNA) NM_022776 NM_176840 RefSeq (protein) NP_073613 NP_789810 Location (UCSC) Chr 3: 125.53 – 125.6 Mb Chr 16: 33.01 – 33.06 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Oxysterol-binding protein-related protein 11 is a protein that in humans is encoded by the OSBPL11 gene.

Function

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000144909 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000022807 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ "Entrez Gene: OSBPL11 oxysterol binding protein-like 11".

Further reading

• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Lehto M, Laitinen S, Chinetti G, Johansson M, Ehnholm C, Staels B, Ikonen E, Olkkonen VM (August 2001). "The OSBP-related protein family in humans". Journal of Lipid Research. 42 (8): 1203–13. doi:10.1016/S0022-2275(20)31570-4. PMID 11483621.
• Jaworski CJ, Moreira E, Li A, Lee R, Rodriguez IR (December 2001). "A family of 12 human genes containing oxysterol-binding domains". Genomics. 78 (3): 185–96. doi:10.1006/geno.2001.6663. PMID 11735225.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

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