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| Names | |
|---|---|
| Preferred IUPAC name Octacosan-1-ol | |
| Other names n-Octacosanol; Octacosyl alcohol; Octanosol; Montanyl alcohol; Cluytyl alcohol | |
| Identifiers | |
| CAS Number | |
| 3D model (JSmol) | |
| ChEBI | |
| ChemSpider | |
| ECHA InfoCard | 100.008.348 
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| KEGG | |
| MeSH | 1-octacosanol |
| PubChem CID | |
| UNII | |
| CompTox Dashboard (EPA) | |
InChI
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SMILES
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| Properties | |
| Chemical formula | C28H58O |
| Molar mass | 410.771 g·mol |
| Melting point | 83 °C (181 °F; 356 K) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa).
 N verify (what is ?)
Infobox references
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1-Octacosanol (also known as n-octacosanol, octacosyl alcohol, cluytyl alcohol, montanyl alcohol) is a straight-chain aliphatic 28-carbon primary fatty alcohol that is common in the epicuticular waxes of plants, including the leaves of many species of Eucalyptus, of most forage and cereal grasses, of Acacia, Trifolium, Pisum and many other legume genera among many others, sometimes as the major wax constituent. Octacosanol also occurs in wheat germ.
Chemistry
Octacosanol is insoluble in water but freely soluble in low molecular-weight alkanes and in chloroform.
Biological effects
Octacosanol is the main component in the mixture policosanol. Octacosanol has been subject to preliminary study for its potential benefit for patients with Parkinson's disease. Studies have also found that octacosanol may inhibit the production of cholesterol. In mice, octacosanol reduces stress and restores stress-affected sleep back to normal.
References
- EA Baker (1982) Chemistry and morphology of plant epicuticular waxes. pp. 139–165. In "The Plant Cuticle". edited by DF Cutler, KL Alvin and CE Price. Academic Press, London. ISBN 0-12-199920-3
- "Octacosanol". Natural Products (Professional). drugs.com. Archived from the original on 3 June 2009. Retrieved 9 July 2009.
isolated from wheat germ oil or other plants
- ^ Taylor, Johanna C; Rapport, Lisa; Lockwood, G.Brian (2003). "Octacosanol in human health". Nutrition. 19 (2): 192–5. doi:10.1016/S0899-9007(02)00869-9. PMID 12591561.
- Snider, SR (1984). "Octacosanol in parkinsonism". Annals of Neurology. 16 (6): 723. doi:10.1002/ana.410160615. PMID 6395790. S2CID 43313071.
- Wang, T; Liu, YY; Wang, X; Yang, N; Zhu, HB; Zuo, PP (2010). "Protective effects of octacosanol on 6-hydroxydopamine-induced Parkinsonism in rats via regulation of ProNGF and NGF signaling". Acta Pharmacologica Sinica. 31 (7): 765–74. doi:10.1038/aps.2010.69. PMC 4007727. PMID 20581854.
- Kaushik, MK; Aritake, K; Takeuchi, A; Yanagisawa, M; Urade, Y (21 August 2017). "Octacosanol restores stress-affected sleep in mice by alleviating stress". Scientific Reports. 7 (1): 8892. Bibcode:2017NatSR...7.8892K. doi:10.1038/s41598-017-08874-2. PMC 5566941. PMID 28827687.
