Opus One may refer to:
- "Opus No. 1", a tune by Sy Oliver and Sid Garris
- "Opus Number One", a composition known for its use as music on hold
- Opus 1 (album), by Yugoslav progressive rock band Opus
- Opus One Winery, United States
- An alternative title for the 1971 demo versions of Mike Oldfield's 1973 album, Tubular Bells
See also
- Op. 1
- Opus number, numbers assigned to musical compositions
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