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Ormosil

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Organically-modified silica or silicate

Ormosil is a shorthand phrase for organically modified silica or organically modified silicate. In general, ormosils are produced by adding silane to silica-derived gel during the sol-gel process. They are engineered materials that show great promise in a wide range of applications such as:

This technology has been demonstrated as a nonviral vector to successfully deliver DNA loads to specifically targeted cells in living animals. Confirmation of results demonstrated that new DNA was working and expressed genes in the animal.

Sono-Ormosil

Sono-Ormosils are organically modified silicates, which were prepared by using high-performance ultrasound during the sol-gel process. When high intense ultrasound is introduced in liquid, cavitation is produced. Due to the cavitational shear forces, molecular weight is lowered by particle size reduction and polydispersity is achieved. Multiphase systems are dispersed and emulsified very efficiently, so that very fine mixtures are prepared. This means that ultrasound accelerates the polymerization significantly over conventional stirring. The resulting polymer shows a higher molecular weight with a lower polydispersity. The product is a molecular-scaled composite material with improved mechanical properties. Sono-Ormosils are distinguished in comparison with conventional gels by a higher density as well as improved thermal stability. This may be a result from the higher degree of polymerization.

See also

References

  1. Li CY, et al. (1992). MacKenzie JD (ed.). "ORMOSILS as matrices in inorganic-organic nanocomposites for various optical applications". Proc. SPIE. Sol-Gel Optics II. 1758 — Sol-Gel Optics II: 410–9. Bibcode:1992SPIE.1758..410L. doi:10.1117/12.132033.
  2. For biotechnological applications of nanoparticles in general, see e.g.
    Salata O (April 2004). "Applications of nanoparticles in biology and medicine". Journal of Nanobiotechnology. 2 (1): 3. doi:10.1186/1477-3155-2-3. PMC 419715. PMID 15119954..
  3. Ellen Goldbaum, Using nanoparticles, in vivo gene therapy activates brain stem cells; Medical News Today, 2005 July. Accessed 2007 May.
  4. Yin, F.; et al. (2015). "Folic acid-conjugated organically modified silica nanoparticles for enhanced targeted delivery in cancer cells and tumor in vivo". Journal of Materials Chemistry B. 3 (29): 6081–6093. doi:10.1039/C5TB00587F.
  5. Scandura, G.; et al. (2016). "Nanoflower‐like Bi2WO6 encapsulated in ORMOSIL as a novel photocatalytic antifouling and foul‐release coating". Chemistry: A European Journal. 22 (21): 7063–7067. doi:10.1002/chem.201600831. PMID 26945837.
  6. Crombie JF (5 May 2006). "Coating protects organic materials from photodegradation". Chemical Technology.
    Parejo PG, Zayat M, Levy D (2006). "Highly efficient UV-absorbing thin-film coatings for protection of organic materials against photodegradation". J. Mater. Chem. 16 (22): 2165–9. doi:10.1039/b601577h.
  7. F. J. Duarte, Solid-state multiple-prism grating dye-laser oscillator, Appl. Opt. 33, 3857-3860 (1994).
  8. Rosa-Fox, N. de la; Pinero, M.; Esquivias, L. (2002): Organic-Inorganic Hybrid Materials from Sonogels. 2002nd
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  • According to my knowledge cutoff, Carbazole alkaloids are a class of compounds that have garnered significant attention in recent years due to their diverse range of biological and pharmacological activities. Here are a few recent discussions and findings related to Carbazole alkaloids:

    1. **Antimicrobial Properties**: A 2020 study published in the Journal of Natural Products explored the antimicrobial properties of Carbazole alkaloids isolated from the plant Piper auritum. The researchers found that these compounds exhibited broad-spectrum antimicrobial activity against various bacterial and fungal strains, including methicillin-resistant Staphylococcus aureus (MRSA).
    2. **Anti-inflammatory and Antioxidant Activities**: A 2019 study published in the Journal of Ethnopharmacology investigated the anti-inflammatory and antioxidant properties of Carbazole alkaloids from the plant Trachelospermum jasminoides. The findings suggested that these compounds may have potential therapeutic applications in the treatment of inflammatory disorders and oxidative stress-related diseases.
    3. **Chemotaxonomy and Biosynthesis**: A 2018 article in the journal Phytochemistry discussed the chemotaxonomic significance of Carbazole alkaloids in the context of plant classification and biosynthesis. The authors highlighted the importance of these compounds in understanding the evolutionary relationships among plant species.
    4. **Pharmacopharmacology and Drug Development**: A 2017 review published in the Journal of Medicinal Chemistry summarized the pharmacopharmacological properties and potential therapeutic applications of Carbazole alkaloids. The authors discussed the promising activities of these compounds in various Disease areas, including cancer, HIV, and malaria.

    These are just a few examples of the recent discussions and findings related to Carbazole alkaloids. If you'd like more information or specific references, please let me know!
    @WNJQ researching the topic Carbazole alkaloids
@WNJQ: According to my knowledge cutoff, Carbazole alkaloids are a class of compounds that have garnered significant attention in recent years due to their diverse range of biological and pharmacological activities. Here are a few recent discussions and findings related to Carbazole alkaloids: 1. ...
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