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PKD1L1
Identifiers
Aliases	PKD1L1, PRO19563, polycystin 1 like 1, transient receptor potential channel interacting, HTX8
External IDs	OMIM: 609721; MGI: 2156538; HomoloGene: 51376; GeneCards: PKD1L1; OMA:PKD1L1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7p12.3 Start 47,740,202 bp End 47,948,466 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle apex of heart gonad left ventricle left testis muscle of thigh epithelium of colon right testis gastrocnemius muscle right auricle n/a More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding calcium channel activity Cellular component integral component of membrane plasma membrane cell projection cilium calcium channel complex membrane ciliary membrane non-motile cilium Biological process ion transport detection of nodal flow detection of mechanical stimulus calcium ion transmembrane transport left/right axis specification calcium ion transport cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 168507 171395 Ensembl ENSG00000158683 n/a UniProt Q8TDX9 n/a RefSeq (mRNA) NM_138295 XM_036157131 RefSeq (protein) NP_612152 n/a Location (UCSC) Chr 7: 47.74 – 47.95 Mb n/a PubMed search
Wikidata
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Polycystin 1 like 1, transient receptor potential channel interacting is a protein that in humans is encoded by the PKD1L1 gene.

Function

This gene encodes a member of the polycystin protein family containing 11 transmembrane domains, a receptor for egg jelly (REJ) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. The encoded protein may play a role in the male reproductive system. Alternative splice variants have been described but their biological nature has not been determined. .

References

1. ^ GRCh38: Ensembl release 89: ENSG00000158683 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: Polycystin 1 like 1, transient receptor potential channel interacting". Retrieved 2017-10-16.

Further reading

• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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