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PRSS16
Identifiers
Aliases	PRSS16, TSSP, protease, serine 16, serine protease 16
External IDs	OMIM: 607169; MGI: 1859181; HomoloGene: 38106; GeneCards: PRSS16; OMA:PRSS16 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p22.1 Start 27,247,701 bp End 27,256,624 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13 A3.1|13 8.12 cM Start 22,186,343 bp End 22,193,912 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thymus body of pancreas mucosa of transverse colon rectum right lobe of thyroid gland left lobe of thyroid gland right uterine tube palpebral conjunctiva duodenum minor salivary glands Top expressed in thymus stroma of bone marrow granulocyte yolk sac morula embryo embryo blastocyst endothelial cell of lymphatic vessel tibiofemoral joint More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity serine-type peptidase activity hydrolase activity dipeptidyl-peptidase activity Cellular component endosome lysosome cytoplasmic vesicle Biological process protein catabolic process proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10279 54373 Ensembl ENSG00000112812 ENSMUSG00000006179 UniProt Q9NQE7 Q9QXE5 RefSeq (mRNA) NM_005865 NM_019429 RefSeq (protein) NP_005856 NP_062302 Location (UCSC) Chr 6: 27.25 – 27.26 Mb Chr 13: 22.19 – 22.19 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Thymus-specific serine protease is an enzyme that in humans is encoded by the PRSS16 gene.

This gene encodes a serine protease expressed exclusively in the thymus. It is thought to play a role in the alternative antigen presenting pathway used by cortical thymic epithelial cells during the positive selection of T cells.

The gene is found in the large histone gene cluster on chromosome 6, near the major histocompatibility complex (MHC) class I region. A second transcript variant has been described, but its full length nature has not been determined.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000112812 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000006179 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bowlus CL, Ahn J, Chu T, Gruen JR (Nov 1999). "Cloning of a novel MHC-encoded serine peptidase highly expressed by cortical epithelial cells of the thymus". Cellular Immunology. 196 (2): 80–6. doi:10.1006/cimm.1999.1543. PMID 10527559.
6. ^ "Entrez Gene: PRSS16 protease, serine, 16 (thymus)".

Further reading

• Lie BA, Viken MK, Akselsen HE, et al. (2007). "Association analysis in type 1 diabetes of the PRSS16 gene encoding a thymus-specific serine protease". Hum. Immunol. 68 (7): 592–8. doi:10.1016/j.humimm.2007.03.009. PMID 17584581.
• Luther C, Wienhold W, Oehlmann R, et al. (2005). "Alternatively spliced transcripts of the thymus-specific protease PRSS16 are differentially expressed in human thymus". Genes Immun. 6 (1): 1–7. doi:10.1038/sj.gene.6364142. PMID 15592422.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Lie BA, Akselsen HE, Bowlus CL, et al. (2003). "Polymorphisms in the gene encoding thymus-specific serine protease in the extended HLA complex: a potential candidate gene for autoimmune and HLA-associated diseases". Genes Immun. 3 (5): 306–12. doi:10.1038/sj.gene.6363858. PMID 12140752.
• Gruen JR, Nalabolu SR, Chu TW, et al. (1997). "A transcription map of the major histocompatibility complex (MHC) class I region". Genomics. 36 (1): 70–85. doi:10.1006/geno.1996.0427. PMID 8812418.

External links

• PRSS16 human gene location in the UCSC Genome Browser.
• PRSS16 human gene details in the UCSC Genome Browser.

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