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PAPPA2
Identifiers
Aliases	PAPPA2, PAPP-A2, PAPP-E, PAPPE, PLAC3, pappalysin 2, SSDA
External IDs	MGI: 3051647; HomoloGene: 10661; GeneCards: PAPPA2; OMA:PAPPA2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q25.2 Start 176,463,171 bp End 176,845,601 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 H1 Start 158,539,297 bp End 158,808,060 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in decidua islet of Langerhans cartilage tissue ventricular zone buccal mucosa cell testicle ganglionic eminence human kidney pancreatic ductal cell stromal cell of endometrium Top expressed in calvaria islet of Langerhans lumbar spinal ganglion Pituitary Gland pontine nuclei trigeminal ganglion dermis lobe of prostate efferent ductule condyle More reference expression data BioGPS n/a
Gene ontology Molecular function zinc ion binding peptidase activity hydrolase activity metallopeptidase activity metal ion binding metalloendopeptidase activity Cellular component extracellular region extracellular exosome intracellular anatomical structure cytosol apical plasma membrane Biological process bone morphogenesis regulation of cell growth proteolysis response to salt stress Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 60676 23850 Ensembl ENSG00000116183 ENSMUSG00000073530 UniProt Q9BXP8 n/a RefSeq (mRNA) NM_020318 NM_021936 NM_001085376 RefSeq (protein) NP_064714 NP_068755 n/a Location (UCSC) Chr 1: 176.46 – 176.85 Mb Chr 1: 158.54 – 158.81 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Pappalysin-2 also known as pregnancy-associated plasma protein A2 (PAPP-A2) is a protein that in humans is encoded by the PAPPA2 gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000116183 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000073530 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Farr M, Strube J, Geppert HG, Kocourek A, Mahne M, Tschesche H (Nov 2000). "Pregnancy-associated plasma protein-E (PAPP-E)". Biochim Biophys Acta. 1493 (3): 356–62. doi:10.1016/s0167-4781(00)00195-0. PMID 11018262.
6. Overgaard MT, Boldt HB, Laursen LS, Sottrup-Jensen L, Conover CA, Oxvig C (Jun 2001). "Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin-like growth factor-binding protein-5 proteinase". J Biol Chem. 276 (24): 21849–53. doi:10.1074/jbc.M102191200. PMID 11264294.
7. "Entrez Gene: PAPPA2 pappalysin 2".

Further reading

• Firth SM, Baxter RC (2003). "Cellular actions of the insulin-like growth factor binding proteins". Endocr. Rev. 23 (6): 824–54. doi:10.1210/er.2001-0033. PMID 12466191.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Page NM, Butlin DJ, Lomthaisong K, Lowry PJ (2001). "The characterization of pregnancy associated plasma protein-E and the identification of an alternative splice variant". Placenta. 22 (8–9): 681–7. doi:10.1053/plac.2001.0709. PMID 11597188.
• Ständker L, Wobst P, Mark S, Forssmann WG (1999). "Isolation and characterization of circulating 13-kDa C-terminal fragments of human insulin-like growth factor binding protein-5". FEBS Lett. 441 (2): 281–6. doi:10.1016/S0014-5793(98)01497-5. PMID 9883900.

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