Pignatelli (Italian pronunciation: [piɲɲaˈtɛlli]) is an Italian surname which may refer to:
People
- House of Pignatelli, an aristocratic family of Naples
- Fabio Pignatelli (born 1953), an Italian musician
- Luca Pignatelli (born 1962), an Italian artist
- William Pignatelli (born 1959), an American state politician from Massachusetts
Places
- Villa Pignatelli, a museum in Naples
- Santa Maria Assunta dei Pignatelli, a church in Naples
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