Piojo is Spanish for louse. Piojo may also refer to:
Places
- Rancho El Piojo, Mexican land-grant in present day California
- Isla Piojo, island in the Gulf of California
- Piojó, a municipality and town in the Colombian department of Atlántico
People
- Los Piojos, Argentine rock band
- Miguel Herrera (born 1968), a Mexican former football defender and manager known as Piojo
- Claudio López (footballer) (born 1974), Argentine football forward known as Piojo
- Piojo (footballer, born 1985), Argentine football striker
- Piojo (footballer, born 1989), Spanish football winger
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