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Plasmodium RUF4 RNA

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Plasmodium RNA of unknown function 4
Predicted secondary structure of RUF4
Identifiers
SymbolRUF4
RfamRF01578
Other data
RNA typesRNA
Domain(s)Plasmodium
PDB structuresPDBe

RUF4 is a non-coding RNA (ncRNA) present within the plasmodium genome. Bioinformatic studies predicted that RUF4 was present within the plasmodium genome and the expression of this ncRNA was verified by Northern Blot. The location of this ncRNAs was subsequently mapped within the P. falciparum strain 3DF genome by primer extension. RUF4 is a novel RNA of unknown function but has shown to contain some structural similarity with the H/ACA box snoRNA but no known targets have been identified.

References

  1. Chakrabarti K, Pearson M, Grate L, Sterne-Weiler T, Deans J, Donohue JP, Ares M (November 2007). "Structural RNAs of known and unknown function identified in malaria parasites by comparative genomics and RNA analysis" (Free full text). RNA. 13 (11): 1923–1939. doi:10.1261/rna.751807. PMC 2040097. PMID 17901154.

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