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REG3G
Identifiers
Aliases	REG3G, LPPM429, PAP IB, PAP-1B, PAP1B, PAPIB, REG III, REG-III, UNQ429, regenerating family member 3 gamma
External IDs	OMIM: 609933; MGI: 109406; HomoloGene: 128216; GeneCards: REG3G; OMA:REG3G - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2p12 Start 79,025,686 bp End 79,028,505 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 C3 Start 78,443,252 bp End 78,445,855 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas islet of Langerhans right testis left testis right adrenal gland right adrenal cortex left adrenal gland left adrenal cortex pancreatic ductal cell mucosa of ileum Top expressed in crypt of lieberkuhn of small intestine respiratory epithelium nasal epithelium olfactory epithelium superior surface of tongue duodenum intestinal villus Paneth cell jejunum Ileal epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function carbohydrate binding peptidoglycan binding oligosaccharide binding transmembrane signaling receptor activity Cellular component cytoplasm extracellular region extracellular space Biological process positive regulation of wound healing positive regulation of keratinocyte proliferation negative regulation of keratinocyte differentiation inflammatory response acute-phase response MyD88-dependent toll-like receptor signaling pathway defense response to Gram-positive bacterium antimicrobial humoral response antimicrobial humoral immune response mediated by antimicrobial peptide positive regulation of cell population proliferation response to peptide hormone cell wall disruption in other organism Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 130120 19695 Ensembl ENSG00000143954 ENSMUSG00000030017 UniProt Q6UW15 O09049 RefSeq (mRNA) NM_001008387 NM_001270040 NM_198448 NM_011260 RefSeq (protein) NP_001008388 NP_001256969 NP_940850 NP_035390 Location (UCSC) Chr 2: 79.03 – 79.03 Mb Chr 6: 78.44 – 78.45 Mb PubMed search
Wikidata
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Regenerating islet-derived protein 3 gamma (also Regenerating islet-derived protein III-gamma) is a protein that in humans is encoded by the REG3G gene.

Intestinal paneth cells produce REG3G (or REG3 gamma) via stimulation of toll-like receptors (TLRs) by pathogen-associated molecular patterns (PAMPs). REG3 gamma specifically targets Gram-positive bacteria because it binds to their surface peptidoglycan layer. It is one of several antimicrobial peptides produced by paneth cells.

Notes and references

1. ^ GRCh38: Ensembl release 89: ENSG00000143954 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000030017 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
6. Nata K, Liu Y, Xu L, Ikeda T, Akiyama T, Noguchi N, Kawaguchi S, Yamauchi A, Takahashi I, Shervani NJ, Onogawa T, Takasawa S, Okamoto H (September 2004). "Molecular cloning, expression and chromosomal localization of a novel human REG family gene, REG III". Gene. 340 (1): 161–70. doi:10.1016/j.gene.2004.06.010. PMID 15556304.
7. Laurine E, Manival X, Montgelard C, Bideau C, Bergé-Lefranc JL, Erard M, Verdier JM (March 2005). "PAP IB, a new member of the Reg gene family: cloning, expression, structural properties, and evolution by gene duplication" (PDF). Biochim. Biophys. Acta. 1727 (3): 177–87. doi:10.1016/j.bbaexp.2005.01.011. PMID 15777617. S2CID 24552883.
8. "Entrez Gene: REG3G regenerating islet-derived 3 gamma".
9. Abreu MT (February 2010). "Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function". Nat. Rev. Immunol. 10 (2): 131–44. doi:10.1038/nri2707. PMID 20098461. S2CID 21789611.

Bibliography

• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
• Laurine E, Manival X, Montgelard C, et al. (2005). "PAP IB, a new member of the Reg gene family: cloning, expression, structural properties, and evolution by gene duplication". Biochim. Biophys. Acta. 1727 (3): 177–87. doi:10.1016/j.bbaexp.2005.01.011. PMID 15777617. S2CID 24552883.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Brandl K, Plitas G, Schnabl B, DeMatteo RP, Pamer EG (2007). "MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection". J. Exp. Med. 204 (8): 900–1891. doi:10.1084/jem.20070563. PMC 2118673. PMID 17635956.

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