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RNF34

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Protein-coding gene in the species Homo sapiens
RNF34
Identifiers
AliasesRNF34, CARP-1, CARP1, RFI, RIF, RIFF, hRFI, ring finger protein 34
External IDsOMIM: 608299; MGI: 2153340; HomoloGene: 11839; GeneCards: RNF34; OMA:RNF34 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)
Chromosome 12 (human)Genomic location for RNF34Genomic location for RNF34
Band12q24.31Start121,400,083 bp
End121,430,623 bp
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)
Chromosome 5 (mouse)Genomic location for RNF34Genomic location for RNF34
Band5|5 FStart122,988,111 bp
End123,009,354 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • Skeletal muscle tissue of rectus abdominis

  • Skeletal muscle tissue of biceps brachii

  • triceps brachii muscle

  • glutes

  • ganglionic eminence

  • muscle of thigh

  • gonad

  • middle temporal gyrus

  • Brodmann area 23
Top expressed in
  • zygote

  • secondary oocyte

  • primary oocyte

  • tail of embryo

  • right ventricle

  • medial ganglionic eminence

  • genital tubercle

  • spermatid

  • granulocyte

  • temporal muscle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

80196

80751

Ensembl

ENSG00000170633

ENSMUSG00000029474

UniProt

Q969K3

Q99KR6

RefSeq (mRNA)

NM_194271
NM_001256858
NM_025126
NM_001394208

NM_030564

RefSeq (protein)

NP_001243787
NP_079402
NP_919247

NP_085041

Location (UCSC)Chr 12: 121.4 – 121.43 MbChr 5: 122.99 – 123.01 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

E3 ubiquitin-protein ligase RNF34 is an enzyme that in humans is encoded by the RNF34 gene.

The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000170633Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000029474Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Sasaki S, Nakamura T, Arakawa H, Mori M, Watanabe T, Nagawa H, Croce CM (Jul 2002). "Isolation and characterization of a novel gene, hRFI, preferentially expressed in esophageal cancer". Oncogene. 21 (32): 5024–30. doi:10.1038/sj.onc.1205627. PMID 12118383.
  6. ^ "Entrez Gene: RNF34 ring finger protein 34".

Further reading


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