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S-Glutathionylation is the posttranslational modification of protein cysteine residues by the addition of glutathione, the most abundant and important low-molecular-mass thiol within most cell types.

Protein S-glutathionylation is involved in

• oxidative stress
• nitrosative stress
• preventing irreversible oxidation of protein thiols
• control of cell-signalling pathways by modulating protein function

References

1. ^ Dalle-Donne, Isabella; Rossi, Ranieri; Colombo, Graziano; Giustarini, Daniela; Milzani, Aldo (2009). "Protein S-glutathionylation: A regulatory device from bacteria to humans". Trends in Biochemical Sciences. 34 (2): 85–96. doi:10.1016/j.tibs.2008.11.002. PMID 19135374.

• Post-translational modification