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SAA2
Identifiers
Aliases	SAA2, serum amyloid A2, SAA1, SAA
External IDs	OMIM: 104751; MGI: 98223; GeneCards: SAA2; OMA:SAA2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11p15.1 Start 18,239,223 bp End 18,248,643 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 B3|7 30.51 cM Start 46,361,422 bp End 46,365,124 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver olfactory zone of nasal mucosa salivary gland minor salivary glands lactiferous gland appendix subcutaneous adipose tissue right adrenal cortex left uterine tube gastrocnemius muscle Top expressed in ankle joint left lobe of liver thymus thoracic diaphragm stroma of bone marrow white adipose tissue ciliary body cervix retinal pigment epithelium lactiferous gland More reference expression data BioGPS n/a
Gene ontology Molecular function chemoattractant activity Cellular component extracellular exosome extracellular region high-density lipoprotein particle extracellular space Biological process acute-phase response cell chemotaxis positive chemotaxis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6289 20210 Ensembl ENSG00000134339 ENSMUSG00000040026 UniProt P0DJI9 P04918 RefSeq (mRNA) NM_030754 NM_001127380 NM_011315 RefSeq (protein) NP_001120852 NP_110381 NP_035445 Location (UCSC) Chr 11: 18.24 – 18.25 Mb Chr 7: 46.36 – 46.37 Mb PubMed search
Wikidata
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Serum amyloid A protein is a protein that in humans is encoded by the SAA2 gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000134339 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000040026 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Steel DM, Sellar GC, Uhlar CM, Simon S, DeBeer FC, Whitehead AS (Jul 1993). "A constitutively expressed serum amyloid A protein gene (SAA4) is closely linked to, and shares structural similarities with, an acute-phase serum amyloid A protein gene (SAA2)". Genomics. 16 (2): 447–54. doi:10.1006/geno.1993.1209. PMID 7686132.
6. "Entrez Gene: SAA2 Serum amyloid A2".

Further reading

• Betts JC, Edbrooke MR, Thakker RV, Woo P (1991). "The human acute-phase serum amyloid A gene family: structure, evolution and expression in hepatoma cells". Scand. J. Immunol. 34 (4): 471–82. doi:10.1111/j.1365-3083.1991.tb01570.x. PMID 1656519. S2CID 26076389.
• Zimlichman S, Danon A, Nathan I, Mozes G, Shainkin-Kestenbaum R (1990). "Serum amyloid A, an acute phase protein, inhibits platelet activation". J. Lab. Clin. Med. 116 (2): 180–6. PMID 1697614.
• Steinkasserer A, Weiss EH, Schwaeble W, Linke RP (1990). "Heterogeneity of human serum amyloid A protein. Five different variants from one individual demonstrated by cDNA sequence analysis". Biochem. J. 268 (1): 187–93. doi:10.1042/bj2680187. PMC 1131410. PMID 1971508.
• Woo P, Sipe J, Dinarello CA, Colten HR (1987). "Structure of a human serum amyloid A gene and modulation of its expression in transfected L cells". J. Biol. Chem. 262 (32): 15790–5. doi:10.1016/S0021-9258(18)47798-8. PMID 2890635.
• Kluve-Beckerman B, Dwulet FE, Benson MD (1988). "Human serum amyloid A. Three hepatic mRNAs and the corresponding proteins in one person". J. Clin. Invest. 82 (5): 1670–5. doi:10.1172/JCI113779. PMC 442736. PMID 3183061.
• Kluve-Beckerman B, Long GL, Benson MD (1987). "DNA sequence evidence for polymorphic forms of human serum amyloid A (SAA)". Biochem. Genet. 24 (11–12): 795–803. doi:10.1007/BF00554519. PMID 3800865. S2CID 8124689.
• Meek RL, Hoffman JS, Benditt EP (1986). "Amyloidogenesis. One serum amyloid A isotype is selectively removed from the circulation". J. Exp. Med. 163 (3): 499–510. doi:10.1084/jem.163.3.499. PMC 2188051. PMID 3950541.
• Badolato R, Wang JM, Murphy WJ, Lloyd AR, Michiel DF, Bausserman LL, Kelvin DJ, Oppenheim JJ (1994). "Serum amyloid A is a chemoattractant: induction of migration, adhesion, and tissue infiltration of monocytes and polymorphonuclear leukocytes". J. Exp. Med. 180 (1): 203–9. doi:10.1084/jem.180.1.203. PMC 2191543. PMID 7516407.
• Badolato R, Johnston JA, Wang JM, McVicar D, Xu LL, Oppenheim JJ, Kelvin DJ (1995). "Serum amyloid A induces calcium mobilization and chemotaxis of human monocytes by activating a pertussis toxin-sensitive signaling pathway". J. Immunol. 155 (8): 4004–10. doi:10.4049/jimmunol.155.8.4004. PMID 7561109.
• Xu L, Badolato R, Murphy WJ, Longo DL, Anver M, Hale S, Oppenheim JJ, Wang JM (1995). "A novel biologic function of serum amyloid A. Induction of T lymphocyte migration and adhesion". J. Immunol. 155 (3): 1184–90. doi:10.4049/jimmunol.155.3.1184. PMID 7636186.
• Liepnieks JJ, Kluve-Beckerman B, Benson MD (1995). "Characterization of amyloid A protein in human secondary amyloidosis: the predominant deposition of serum amyloid A1". Biochim. Biophys. Acta. 1270 (1): 81–6. doi:10.1016/0925-4439(94)00076-3. PMID 7827140.
• Arai K, Miura K, Baba S, Shirasawa H (1994). "Transformation from SAA2-fibrils to AA-fibrils in amyloid fibrillogenesis: in vivo observations in murine spleen using anti-SAA and anti-AA antibodies". J. Pathol. 173 (2): 127–34. doi:10.1002/path.1711730209. hdl:10271/1458. PMID 8089807. S2CID 1125165.
• Meek RL, Urieli-Shoval S, Benditt EP (1994). "Expression of apolipoprotein serum amyloid A mRNA in human atherosclerotic lesions and cultured vascular cells: implications for serum amyloid A function". Proc. Natl. Acad. Sci. U.S.A. 91 (8): 3186–90. Bibcode:1994PNAS...91.3186M. doi:10.1073/pnas.91.8.3186. PMC 43540. PMID 8159722.
• Sellar GC, Jordan SA, Bickmore WA, Fantes JA, Van Heyningen V, Whitehead AS (1994). "The human serum amyloid A protein (SAA) superfamily gene cluster: mapping to chromosome 11p15.1 by physical and genetic linkage analysis". Genomics. 19 (2): 221–7. doi:10.1006/geno.1994.1051. PMID 8188252.
• Ducret A, Bruun CF, Bures EJ, Marhaug G, Husby G, Aebersold R (1996). "Characterization of human serum amyloid A protein isoforms separated by two-dimensional electrophoresis by liquid chromatography/electrospray ionization tandem mass spectrometry". Electrophoresis. 17 (5): 866–76. doi:10.1002/elps.1150170508. PMID 8783012. S2CID 35332525.
• Ancsin JB, Kisilevsky R (1997). "Characterization of high affinity binding between laminin and the acute-phase protein, serum amyloid A". J. Biol. Chem. 272 (1): 406–13. doi:10.1074/jbc.272.1.406. PMID 8995276.
• Hershkoviz R, Preciado-Patt L, Lider O, Fridkin M, Dastych J, Metcalfe DD, Mekori YA (1997). "Extracellular matrix-anchored serum amyloid A preferentially induces mast cell adhesion". Am. J. Physiol. 273 (1 Pt 1): C179–87. doi:10.1152/ajpcell.1997.273.1.C179. PMID 9252455.
• Migita K, Kawabe Y, Tominaga M, Origuchi T, Aoyagi T, Eguchi K (1998). "Serum amyloid A protein induces production of matrix metalloproteinases by human synovial fibroblasts". Lab. Invest. 78 (5): 535–9. PMID 9605178.
• Urieli-Shoval S, Cohen P, Eisenberg S, Matzner Y (1999). "Widespread expression of serum amyloid A in histologically normal human tissues. Predominant localization to the epithelium". J. Histochem. Cytochem. 46 (12): 1377–84. doi:10.1177/002215549804601206. PMID 9815279.

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