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SEPSECS
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3HL2, 4ZDO, 4ZDL, 4ZDP
Identifiers
Aliases	SEPSECS, LP, PCH2D, SLA, SLA/LP, Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase, soluble liver antigen, SecS
External IDs	OMIM: 613009; MGI: 1098791; HomoloGene: 15031; GeneCards: SEPSECS; OMA:SEPSECS - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4p15.2 Start 25,120,014 bp End 25,160,550 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5 C1|5 28.44 cM Start 52,797,429 bp End 52,827,050 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum testicle right lobe of liver jejunal mucosa gonad Achilles tendon body of pancreas pancreatic epithelial cell rectum gastric mucosa Top expressed in muscle of thorax islet of Langerhans left lobe of liver thyroid cartilage spermatocyte secondary oocyte right kidney renal pelvis Ileal epithelium zygote More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity tRNA binding selenotransferase activity catalytic activity protein binding RNA binding phosphoseryl-selenocysteinyl-tRNA selenium transferase activity Cellular component cytoplasm cytosol nucleus Biological process selenocysteine incorporation protein biosynthesis selenocysteine metabolic process selenocysteinyl-tRNA(Sec) biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51091 211006 Ensembl ENSG00000109618 ENSMUSG00000029173 UniProt Q9HD40 Q6P6M7 RefSeq (mRNA) NM_001159728 NM_016955 NM_172490 NM_001363463 RefSeq (protein) NP_058651 NP_766078 NP_001350392 Location (UCSC) Chr 4: 25.12 – 25.16 Mb Chr 5: 52.8 – 52.83 Mb PubMed search
Wikidata
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O-phosphoseryl-tRNA(Sec) selenium transferase is an enzyme that in humans is encoded by the SEPSECS gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000109618 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000029173 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Xu XM, Mix H, Carlson BA, Grabowski PJ, Gladyshev VN, Berry MJ, Hatfield DL (Dec 2005). "Evidence for direct roles of two additional factors, SECp43 and soluble liver antigen, in the selenoprotein synthesis machinery". J. Biol. Chem. 280 (50): 41568–75. doi:10.1074/jbc.M506696200. PMID 16230358.
6. Costa M, Rodríguez-Sánchez JL, Czaja AJ, Gelpí C (Aug 2000). "Isolation and characterization of cDNA encoding the antigenic protein of the human tRNP(Ser)Sec complex recognized by autoantibodies from patients with type-1 autoimmune hepatitis". Clin. Exp. Immunol. 121 (2): 364–74. doi:10.1046/j.1365-2249.2000.01280.x. PMC 1905695. PMID 10931155.
7. Yuan J, Palioura S, Salazar JC, Su D, O'Donoghue P, Hohn MJ, Cardoso AM, Whitman WB, Söll D (Dec 2006). "RNA-dependent conversion of phosphoserine forms selenocysteine in eukaryotes and archaea". Proc. Natl. Acad. Sci. U.S.A. 103 (50): 18923–7. Bibcode:2006PNAS..10318923Y. doi:10.1073/pnas.0609703104. PMC 1748153. PMID 17142313.
8. Xu XM, Carlson BA, Mix H, Zhang Y, Saira K, Glass RS, Berry MJ, Gladyshev VN, Hatfield DL (Apr 2007). "Biosynthesis of selenocysteine on its tRNA in eukaryotes". PLOS Biol. 5 (1): e4. doi:10.1371/journal.pbio.0050004. PMC 1717018. PMID 17194211.
9. "Entrez Gene: SLA/LP soluble liver antigen/liver pancreas antigen".

Further reading

• Herkel J, Heidrich B, Nieraad N, Wies I, Rother M, Lohse AW (2002). "Fine specificity of autoantibodies to soluble liver antigen and liver/pancreas". Hepatology. 35 (2): 403–8. doi:10.1053/jhep.2002.30699. PMID 11826415. S2CID 46400743.
• Volkmann M, Martin L, Bäurle A, Heid H, Strassburg CP, Trautwein C, Fiehn W, Manns MP (2001). "Soluble liver antigen: isolation of a 35-kd recombinant protein (SLA-p35) specifically recognizing sera from patients with autoimmune hepatitis". Hepatology. 33 (3): 591–6. doi:10.1053/jhep.2001.22218. PMID 11230739. S2CID 11978013.
• Wies I, Brunner S, Henninger J, Herkel J, Kanzler S, Meyer zum Büschenfelde KH, Lohse AW (2000). "Identification of target antigen for SLA/LP autoantibodies in autoimmune hepatitis". Lancet. 355 (9214): 1510–5. doi:10.1016/S0140-6736(00)02166-8. PMID 10801173. S2CID 45159673.

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