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SEPTIN8
Identifiers
Aliases	SEPTIN8, SEP2, septin 8, SEPT8
External IDs	OMIM: 608418; MGI: 894310; HomoloGene: 57205; GeneCards: SEPTIN8; OMA:SEPTIN8 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) Band 5q31.1 Start 132,750,819 bp End 132,807,241 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 B1.3|11 31.96 cM Start 53,410,084 bp End 53,440,392 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus C1 segment Brodmann area 23 endothelial cell corpus callosum inferior ganglion of vagus nerve postcentral gyrus entorhinal cortex subthalamic nucleus right frontal lobe Top expressed in facial motor nucleus visual cortex primary visual cortex superior frontal gyrus interventricular septum cerebellar cortex Region I of hippocampus proper primary motor cortex anterior horn of spinal cord dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding GTP binding protein binding GTPase activity molecular adaptor activity Cellular component cytoplasm cytoskeleton septin ring microtubule cytoskeleton septin complex septin filament array presynapse membrane cell junction axon synaptic vesicle membrane cytoplasmic vesicle cell projection synapse Biological process mitotic cytokinesis septin ring assembly cilium assembly regulation of SNARE complex assembly cytoskeleton-dependent cytokinesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23176 20362 Ensembl ENSG00000164402 ENSMUSG00000018398 UniProt Q92599 Q8CHH9 RefSeq (mRNA) NM_001098811 NM_001098812 NM_001098813 NM_001300798 NM_001300799 NM_015146 NM_001252332 NM_001252333 NM_033144 NM_001347496 NM_001361968 NM_001361969 RefSeq (protein) NP_001092281 NP_001092282 NP_001092283 NP_001287727 NP_001287728 NP_055961 NP_001239261 NP_001239262 NP_001334425 NP_149156 NP_001348897 NP_001348898 Location (UCSC) Chr 5: 132.75 – 132.81 Mb Chr 11: 53.41 – 53.44 Mb PubMed search
Wikidata
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Septin-8 is a protein that in humans is encoded by the SEPT8 gene.

Function

SEPT8 is a member of the highly conserved septin family. Septins are 40- to 60-kD GTPases that assemble as filamentous scaffolds. They are involved in the organization of submembranous structures, in neuronal polarity, and in vesicle trafficking.

Interactions

SEPT8 has been shown to interact with PFTK1 and SEPT5.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000164402 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000018398 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (October 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
6. Frazer KA, Ueda Y, Zhu Y, Gifford VR, Garofalo MR, Mohandas N, Martin CH, Palazzolo MJ, Cheng JF, Rubin EM (May 1997). "Computational and biological analysis of 680 kb of DNA sequence from the human 5q31 cytokine gene cluster region". Genome Research. 7 (5): 495–512. doi:10.1101/gr.7.5.495. PMID 9149945.
7. ^ "Entrez Gene: SEPT8 septin 8".
8. Yang T, Gao YK, Chen JY (July 2002). "KIAA0202, a human septin family member, interacting with hPFTAIRE1". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica et Biophysica Sinica. 34 (4): 520–5. PMID 12098780.
9. Bläser S, Jersch K, Hainmann I, Zieger W, Wunderle D, Busse A, Zieger B (July 2003). "Isolation of new splice isoforms, characterization and expression analysis of the human septin SEPT8 (KIAA0202)". Gene. 312: 313–20. doi:10.1016/S0378-1119(03)00635-8. PMID 12909369.
10. Bläser S, Jersch K, Hainmann I, Wunderle D, Zgaga-Griesz A, Busse A, Zieger B (May 2002). "Human septin-septin interaction: CDCrel-1 partners with KIAA0202". FEBS Letters. 519 (1–3): 169–72. Bibcode:2002FEBSL.519..169B. doi:10.1016/S0014-5793(02)02749-7. PMID 12023038. S2CID 30822245.

Further reading

• Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Wenderfer SE, Slack JP, McCluskey TS, Monaco JJ (February 2000). "Identification of 40 genes on a 1-Mb contig around the IL-4 cytokine family gene cluster on mouse chromosome 11". Genomics. 63 (3): 354–73. doi:10.1006/geno.1999.6100. PMID 10704283.
• Bläser S, Jersch K, Hainmann I, Wunderle D, Zgaga-Griesz A, Busse A, Zieger B (May 2002). "Human septin-septin interaction: CDCrel-1 partners with KIAA0202". FEBS Letters. 519 (1–3): 169–72. Bibcode:2002FEBSL.519..169B. doi:10.1016/S0014-5793(02)02749-7. PMID 12023038. S2CID 30822245.
• Yang T, Gao YK, Chen JY (July 2002). "KIAA0202, a human septin family member, interacting with hPFTAIRE1". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica et Biophysica Sinica. 34 (4): 520–5. PMID 12098780.
• Macara IG, Baldarelli R, Field CM, Glotzer M, Hayashi Y, Hsu SC, Kennedy MB, Kinoshita M, Longtine M, Low C, Maltais LJ, McKenzie L, Mitchison TJ, Nishikawa T, Noda M, Petty EM, Peifer M, Pringle JR, Robinson PJ, Roth D, Russell SE, Stuhlmann H, Tanaka M, Tanaka T, Trimble WS, Ware J, Zeleznik-Le NJ, Zieger B (December 2002). "Mammalian septins nomenclature". Molecular Biology of the Cell. 13 (12): 4111–3. doi:10.1091/mbc.E02-07-0438. PMC 138619. PMID 12475938.
• Bläser S, Jersch K, Hainmann I, Zieger W, Wunderle D, Busse A, Zieger B (July 2003). "Isolation of new splice isoforms, characterization and expression analysis of the human septin SEPT8 (KIAA0202)". Gene. 312: 313–20. doi:10.1016/S0378-1119(03)00635-8. PMID 12909369.
• Bläser S, Horn J, Würmell P, Bauer H, Strümpell S, Nurden P, Pagenstecher A, Busse A, Wunderle D, Hainmann I, Zieger B (May 2004). "The novel human platelet septin SEPT8 is an interaction partner of SEPT4". Thrombosis and Haemostasis. 91 (5): 959–66. doi:10.1160/TH03-09-0578. PMID 15116257. S2CID 22853459.
• Martínez C, Sanjuan MA, Dent JA, Karlsson L, Ware J (September 2004). "Human septin-septin interactions as a prerequisite for targeting septin complexes in the cytosol". The Biochemical Journal. 382 (Pt 3): 783–91. doi:10.1042/BJ20040372. PMC 1133953. PMID 15214843.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Bläser S, Röseler S, Rempp H, Bartsch I, Bauer H, Lieber M, Lessmann E, Weingarten L, Busse A, Huber M, Zieger B (September 2006). "Human endothelial cell septins: SEPT11 is an interaction partner of SEPT5". The Journal of Pathology. 210 (1): 103–10. doi:10.1002/path.2013. PMID 16767699. S2CID 45797279.
• Xin X, Pache M, Zieger B, Bartsch I, Prünte C, Flammer J, Meyer P (November 2007). "Septin expression in proliferative retinal membranes". The Journal of Histochemistry and Cytochemistry. 55 (11): 1089–94. doi:10.1369/jhc.7A7188.2007. PMC 3957527. PMID 17625225.

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