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SH3BP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4J9D, 4J9F
Identifiers
Aliases	SH3BP1, ARHGAP43, SH3 domain binding protein 1
External IDs	OMIM: 617368; MGI: 104603; HomoloGene: 7534; GeneCards: SH3BP1; OMA:SH3BP1 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) Band 22q13.1 Start 37,634,654 bp End 37,656,117 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 E1 Start 78,783,968 bp End 78,796,251 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte mucosa of transverse colon skin of abdomen spleen skin of leg rectum lymph node blood appendix Top expressed in granulocyte lip yolk sac esophagus mesenteric lymph nodes thymus superior frontal gyrus genital tubercle tail of embryo primary visual cortex More reference expression data BioGPS n/a
Gene ontology Molecular function SH3 domain binding protein binding GTPase activator activity semaphorin receptor binding Cellular component cytoplasm exocyst lamellipodium phagocytic cup nucleus cytosol adherens junction bicellular tight junction cell junction cell projection cell leading edge intracellular anatomical structure Biological process signal transduction phagocytosis, engulfment actin filament organization regulation of actin filament depolymerization regulation of actin cytoskeleton organization cell junction assembly regulation of blood vessel endothelial cell migration establishment of epithelial cell apical/basal polarity negative regulation of small GTPase mediated signal transduction semaphorin-plexin signaling pathway phagocytosis cell migration positive regulation of GTPase activity filopodium assembly ruffle assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23616 20401 Ensembl ENSG00000100092 ENSMUSG00000022436 UniProt Q9Y3L3 P55194 RefSeq (mRNA) NM_018957 NM_001350055 NM_009164 NM_001316684 NM_001316685 NM_001316686 RefSeq (protein) NP_061830 NP_001336984 NP_001303613 NP_001303614 NP_001303615 NP_033190 Location (UCSC) Chr 22: 37.63 – 37.66 Mb Chr 15: 78.78 – 78.8 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

SH3 domain-binding protein 1 is a protein that in humans is encoded by the SH3BP1 gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000100092 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000022436 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
6. Scott MP, Zappacosta F, Kim EY, Annan RS, Miller WT (Jul 2002). "Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1". J Biol Chem. 277 (31): 28238–46. doi:10.1074/jbc.M202783200. PMID 12029088.
7. "Entrez Gene: SH3BP1 SH3-domain binding protein 1".

Further reading

• Cicchetti P, Mayer BJ, Thiel G, Baltimore D (1992). "Identification of a protein that binds to the SH3 region of Abl and is similar to Bcr and GAP-rho". Science. 257 (5071): 803–6. Bibcode:1992Sci...257..803C. doi:10.1126/science.1379745. PMID 1379745.
• Zhang B, Zheng Y (1998). "Regulation of RhoA GTP hydrolysis by the GTPase-activating proteins p190, p50RhoGAP, Bcr, and 3BP-1". Biochemistry. 37 (15): 5249–57. doi:10.1021/bi9718447. PMID 9548756.
• Västrik I, Eickholt BJ, Walsh FS, et al. (2000). "Sema3A-induced growth-cone collapse is mediated by Rac1 amino acids 17-32". Curr. Biol. 9 (18): 991–8. doi:10.1016/S0960-9822(99)80447-3. PMID 10508610.
• So CW, So CK, Cheung N, et al. (2000). "The interaction between EEN and Abi-1, two MLL fusion partners, and synaptojanin and dynamin: implications for leukaemogenesis". Leukemia. 14 (4): 594–601. doi:10.1038/sj.leu.2401692. PMID 10764144.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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