Misplaced Pages

SPRR1A
Identifiers
Aliases	SPRR1A, SPRK, small proline rich protein 1A
External IDs	OMIM: 182265; MGI: 106660; HomoloGene: 105698; GeneCards: SPRR1A; OMA:SPRR1A - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q21.3 Start 152,984,081 bp End 152,985,814 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3 F1|3 40.14 cM Start 92,391,259 bp End 92,393,202 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gums gingival epithelium mucosa of pharynx body of tongue human penis buccal mucosa cell oral cavity vulva amniotic fluid superior surface of tongue Top expressed in transitional epithelium of urinary bladder lip esophagus pyloric antrum mucous cell of stomach skin of external ear cervix skin of back hair follicle skin of abdomen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-macromolecule adaptor activity protein binding structural molecule activity structural constituent of skin epidermis Cellular component cytoplasm cornified envelope cytosol Biological process peptide cross-linking keratinization keratinocyte differentiation epidermis development cornification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6698 20753 Ensembl ENSG00000169474 ENSMUSG00000050359 UniProt P35321 Q62266 RefSeq (mRNA) NM_005987 NM_001199828 NM_009264 RefSeq (protein) NP_001186757 NP_005978 NP_033290 Location (UCSC) Chr 1: 152.98 – 152.99 Mb Chr 3: 92.39 – 92.39 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Cornifin-A is a protein that in humans is encoded by the SPRR1A gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000169474 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000050359 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gibbs S, Fijneman R, Wiegant J, van Kessel AG, van De Putte P, Backendorf C (June 1993). "Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins". Genomics. 16 (3): 630–7. doi:10.1006/geno.1993.1240. PMID 8325635.
6. "Entrez Gene: SPRR1A small proline-rich protein 1A".

Further reading

• Greco MA, Lorand L, Lane WS, Baden HP, Parameswaran KN, Kvedar JC (February 1995). "The pancornulins: a group of small proline rich-related cornified envelope precursors with bifunctional capabilities in isopeptide bond formation". The Journal of Investigative Dermatology. 104 (2): 204–10. doi:10.1111/1523-1747.ep12612759. PMID 7829876.
• Robinson PA, Marley JJ, High AS, Hume WJ (March 1994). "Differential expression of protease inhibitor and small proline-rich protein genes between normal human oral tissue and odontogenic keratocysts". Archives of Oral Biology. 39 (3): 251–9. doi:10.1016/0003-9969(94)90051-5. PMID 8018055.
• Fujimoto W, Nakanishi G, Arata J, Jetten AM (February 1997). "Differential expression of human cornifin alpha and beta in squamous differentiating epithelial tissues and several skin lesions". The Journal of Investigative Dermatology. 108 (2): 200–4. doi:10.1111/1523-1747.ep12334240. PMID 9008234.
• Robinson NA, Lapic S, Welter JF, Eckert RL (May 1997). "S100A11, S100A10, annexin I, desmosomal proteins, small proline-rich proteins, plasminogen activator inhibitor-2, and involucrin are components of the cornified envelope of cultured human epidermal keratinocytes". The Journal of Biological Chemistry. 272 (18): 12035–46. doi:10.1074/jbc.272.18.12035. PMID 9115270.
• Reddy SP, Konkin T, Wu R (December 1998). "Structure and organization of the genes encoding mouse small proline-rich proteins, mSPRR1A and 1B". Gene. 224 (1–2): 59–66. doi:10.1016/S0378-1119(98)00507-1. PMID 9931436.
• Candi E, Tarcsa E, Idler WW, Kartasova T, Marekov LN, Steinert PM (March 1999). "Transglutaminase cross-linking properties of the small proline-rich 1 family of cornified cell envelope proteins. Integration with loricrin". The Journal of Biological Chemistry. 274 (11): 7226–37. doi:10.1074/jbc.274.11.7226. PMID 10066784.
• Lee CH, Marekov LN, Kim S, Brahim JS, Park MH, Steinert PM (July 2000). "Small proline-rich protein 1 is the major component of the cell envelope of normal human oral keratinocytes". FEBS Letters. 477 (3): 268–72. doi:10.1016/S0014-5793(00)01806-8. PMID 10908733.
• Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Cabral A, Voskamp P, Cleton-Jansen AM, South A, Nizetic D, Backendorf C (June 2001). "Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function". The Journal of Biological Chemistry. 276 (22): 19231–7. doi:10.1074/jbc.M100336200. PMID 11279051.
• Bonilla IE, Tanabe K, Strittmatter SM (February 2002). "Small proline-rich repeat protein 1A is expressed by axotomized neurons and promotes axonal outgrowth". The Journal of Neuroscience. 22 (4): 1303–15. doi:10.1523/JNEUROSCI.22-04-01303.2002. PMC 6757578. PMID 11850458.

This article on a gene on human chromosome 1 is a stub. You can help Misplaced Pages by expanding it.

• v
• t
• e

• Genes on human chromosome 1
• Human chromosome 1 gene stubs