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SPSB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JK9, 3F2O
Identifiers
Aliases	SPSB1, SSB-1, SSB1, splA/ryanodine receptor domain and SOCS box containing 1
External IDs	OMIM: 611657; MGI: 1921896; HomoloGene: 11832; GeneCards: SPSB1; OMA:SPSB1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p36.22 Start 9,292,894 bp End 9,369,532 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 E2 Start 149,980,740 bp End 150,039,500 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in decidua Descending thoracic aorta ascending aorta tibial arteries gastric mucosa saphenous vein gallbladder vena cava right coronary artery left coronary artery Top expressed in decidua cumulus cell gastrula cardiac muscle tissue of left ventricle molar ascending aorta epithelium of lens aortic valve tunica media of zone of aorta ankle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding ubiquitin-protein transferase activity ubiquitin ligase-substrate adaptor activity Cellular component cytoplasm cytosol SCF ubiquitin ligase complex Biological process protein ubiquitination protein polyubiquitination post-translational protein modification ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80176 74646 Ensembl ENSG00000171621 ENSMUSG00000039911 UniProt Q96BD6 Q9D5L7 RefSeq (mRNA) NM_025106 NM_029035 RefSeq (protein) NP_079382 NP_083311 Location (UCSC) Chr 1: 9.29 – 9.37 Mb Chr 4: 149.98 – 150.04 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

SPRY domain-containing SOCS box protein 1 is a protein that in humans is encoded by the SPSB1 gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000171621 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000039911 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wang D, Li Z, Messing EM, Wu G (Apr 2005). "The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway". J Biol Chem. 280 (16): 16393–401. doi:10.1074/jbc.M413897200. PMID 15713673.
6. Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (Jun 2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
7. "Entrez Gene: SPSB1 splA/ryanodine receptor domain and SOCS box containing 1".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Woo JS, Imm JH, Min CK, et al. (2006). "Structural and functional insights into the B30.2/SPRY domain". EMBO J. 25 (6): 1353–63. doi:10.1038/sj.emboj.7600994. PMC 1422157. PMID 16498413.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

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