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STEAP1

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Protein-coding gene in the species Homo sapiens
STEAP1
Identifiers
AliasesSTEAP1, PRSS24, STEAP, six transmembrane epithelial antigen of the prostate 1, STEAP family member 1
External IDsOMIM: 604415; MGI: 1917608; HomoloGene: 8256; GeneCards: STEAP1; OMA:STEAP1 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)
Chromosome 7 (human)Genomic location for STEAP1Genomic location for STEAP1
Band7q21.13Start90,154,456 bp
End90,164,829 bp
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)
Chromosome 5 (mouse)Genomic location for STEAP1Genomic location for STEAP1
Band5 A1|5 3.2 cMStart5,786,317 bp
End5,799,326 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pericardium

  • cartilage tissue

  • prostate

  • tendon of biceps brachii

  • Achilles tendon

  • parietal pleura

  • gonad

  • mucosa of transverse colon

  • abdominal fat

  • gallbladder
Top expressed in
  • Epithelium of choroid plexus

  • endothelial cell of lymphatic vessel

  • lumbar spinal ganglion

  • epithelium of lens

  • molar

  • hair follicle

  • yolk sac

  • adrenal gland

  • Paneth cell

  • iris
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26872

70358

Ensembl

ENSG00000164647

ENSMUSG00000015652

UniProt

Q9UHE8

Q9CWR7

RefSeq (mRNA)

NM_012449

NM_027399

RefSeq (protein)

NP_036581

NP_081675

Location (UCSC)Chr 7: 90.15 – 90.16 MbChr 5: 5.79 – 5.8 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Metalloreductase STEAP1 is an enzyme that in humans is encoded by the STEAP1 gene.

This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000164647Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000015652Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: STEAP1 six transmembrane epithelial antigen of the prostate 1".

Further reading


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