Santayana is a Spanish surname. Notable people with the surname include:
- Alfonso Pardo de Santayana y Coloma (1936–2015), Spanish military officer
- Antonio Gutiérrez de Otero y Santayana (1729–1799), Spanish lieutenant general
- George Santayana (1863–1952), Spanish-American philosopher
Surname listThis page lists people with the surname Santayana. If an internal link intending to refer to a specific person led you to this page, you may wish to change that link by adding the person's given name(s) to the link. Categories: